Abstract:
:Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for development and sustenance of definitive hematopoiesis during mouse embryogenesis. Bro and Bgb are required for Runt/Lozenge functions in Drosophila development. CBFbeta contributes to leukemogenesis since the CBFB gene is specifically and consistently mutated by a chromosome 16 inversion found in patients with acute myeloid leukemia subtype M4Eo. The ubiquitous expression pattern of the CBFB gene suggests that it may play important roles in many other organ systems.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Adya N,Castilla LH,Liu PPdoi
10.1006/scdb.2000.0189subject
Has Abstractpub_date
2000-10-01 00:00:00pages
361-8issue
5eissn
1084-9521issn
1096-3634pii
S1084-9521(00)90189-7journal_volume
11pub_type
杂志文章,评审abstract::Both cell cycle progression and the ubiquitin-proteasome system (UPS) that drives it are precisely regulated. Enzymatically, many ubiquitylation and degradation reactions have been characterized in in vitro systems, providing insights into the fundamental mechanisms of the UPS. Biologically, a range of degradation eve...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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