Abstract:
:Skeletal muscle cells possess a unique cellular architecture designed to fulfill their contractile function. Muscle cells (also known as myofibers) result from the fusion of hundreds of myoblasts and grow into a fiber of several centimeters in length. Cellular structures gradually become organized during muscle development to raise a mature contractile cell. A hallmark of this singular cell architecture is the position of nuclei at the periphery of the myofiber, below the plasma membrane. Nuclei in myofibers are evenly distributed except in specialized regions like the neuromuscular or myotendinous junctions. Disruption of nuclear positioning results in hindered muscle contraction and occurs in a multitude of muscle disorders as well as in regenerative myofibers. We will explore in this review the step by step nuclear migrations during myogenesis for nuclei to reach their evenly distributed anchored position at the periphery.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Roman W,Gomes ERdoi
10.1016/j.semcdb.2017.11.005subject
Has Abstractpub_date
2018-10-01 00:00:00pages
51-56eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30428-7journal_volume
82pub_type
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