Abstract：
:During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to establish different neural progenitor cell populations, defined by the expression of homeodomain transcription factors. These factors are critical for the interpretation of graded Shh signalling and act initially both to refine progenitor domain boundaries and to maintain their integrity. Subsequently, these factors direct the expression of genes that confer neuronal subtype identity to post-mitotic neurons.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Briscoe J,Ericson Jdoi
10.1006/scdb.1999.0295subject
Has Abstractpub_date
1999-06-01 00:00:00pages
353-62issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(99)90295-1journal_volume
10pub_type
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