Abstract:
:Cells maintain a cholesterol gradient across the secretory system, with the lowest concentrations in the endoplasmic reticulum (ER) and the highest in the plasma membrane (PM). Cholesterol is also heterogeneously distributed in the endocytic pathway. Little is known about how this heterogeneous distribution of cholesterol is maintained despite continuous vesicular traffic between organelles. Both the modulation of the cholesterol content of transport vesicles and the non-vesicular transport of cholesterol between organelles are likely to contribute. This review summarizes what is known about the pathways and mechanisms of intracellular sterol trafficking.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Prinz Wdoi
10.1016/s1084-9521(02)00048-4subject
Has Abstractpub_date
2002-06-01 00:00:00pages
197-203issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(02)00048-4journal_volume
13pub_type
杂志文章,评审abstract::Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 198...
journal_title:Seminars in cell & developmental biology
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abstract::Differences between sexes of the same species in lifespan and aging rate are widespread. While the proximal and evolutionary causes of aging are well researched, the factors that contribute to sex differences in these traits have been less studied. The striking diversity of nematodes provides ample opportunity to stud...
journal_title:Seminars in cell & developmental biology
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abstract::Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. Th...
journal_title:Seminars in cell & developmental biology
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abstract::The family Cichlidae contains approximately 2000 species that live in diverse freshwater habitats including murky lakes, turbid rivers, and clear lakes from both the Old and New Worlds. Their visual systems are similarly diverse and have evolved specific sensitivities that differ along several axes of variation. Varia...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
abstract::For over a decade, studies of messenger RNA regulation have revealed an unprecedented level of connectivity between the RNA pool and global gene expression. These connections are underpinned by a vast array of RNA elements that coordinate RNA-protein and RNA-RNA interactions, each directing mRNA fate from transcriptio...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::Human SERPINB3 and SERPINB4 are evolutionary duplicated serine/cysteine protease inhibitors. Genomic analysis indicates that these paralogous genes were encoded from independent loci arising from tandem gene duplication. Although the two molecules share 92% identity of their amino acid sequences, they are distinct in ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
abstract::Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
abstract::Sex-determination is commonly categorized as either "genetic" or "environmental"-a classification that obscures the origin of this dichotomy and the evolution of sex-determining factors. The current focus on static outcomes of sex-determination provides little insight into the dynamic developmental processes by which ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2008.11.013
更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.09.033
更新日期:2018-05-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.09.011
更新日期:2012-10-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.12.016
更新日期:2018-12-01 00:00:00
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to unde...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2013.03.012
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abstract::Centrioles and basal bodies are MT based structures that present a highly conserved ninefold symmetry. Centrioles can be found at the core of the centrosome where they participate in PCM recruitment and organization, contributing to cytoplasmic MT nucleation. Basal bodies are normally located closely to the plasma mem...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::Some epithelial cells are polarized along an axis orthogonal to their apical-basal axes. Recent studies in Drosophila lead to the view that three classes of signaling molecules govern the planar cell polarity (PCP) pathway. The first class, or module, functions across whole tissues, providing directional information t...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::The role of the tight junctions (TJ) in controlling paracellular traffic of ions and molecules, through the regulation of claudin proteins, is now established. However, it has also become increasingly evident that claudin proteins, as integral components of the TJs, play crucial role in maintaining the cell-cell integ...
journal_title:Seminars in cell & developmental biology
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abstract::Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::Pollen tubes extend rapidly in an oscillatory manner by the extreme form of polarized growth, tip growth, and provide an exciting system for studying the spatiotemporal control of polarized cell growth. The Rho-family ROP GTPase is a key signaling molecule in this growth control and is periodically activated at the ap...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.06.004
更新日期:2011-10-01 00:00:00
abstract::Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...
journal_title:Seminars in cell & developmental biology
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