当前位置： SCI文献检索 > SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY期刊下所有文献 > From ABC genes to regulatory networks, epigenetic landscapes and flower morphogenesis: making biological sense of theoretical approaches.

From ABC genes to regulatory networks, epigenetic landscapes and flower morphogenesis: making biological sense of theoretical approaches.

Abstract：

:The ABC model postulates that expression combinations of three classes of genes (A, B and C) specify the four floral organs at early stages of flower development. This classic model provides a solid framework to study flower development and has been the foundation for multiple studies in different plant species, as well as for new evolutionary hypotheses. Nevertheless, it has been shown that in spite of being necessary, these three gene classes are not sufficient for flower organ specification. Rather, flower organ specification depends on complex interactions of several genes, and probably other non-genetic factors. Being useful to study systems of complex interactions, mathematical and computational models have enlightened the origin of the A, B and C stereotyped and robust expression patterns and the process of early flower morphogenesis. Here, we present a brief introduction to basic modeling concepts and techniques and review the results that these models have rendered for the particular case of the Arabidopsis thaliana flower organ specification. One of the main results is the uncovering of a robust functional module that is sufficient to recover the gene configurations characterizing flower organ primordia. Another key result is that the temporal sequence with which such gene configurations are attained may be recovered only by modeling the aforementioned functional module as a noisy or stochastic system. Finally, modeling approaches enable testable predictions regarding the role of non-genetic factors (noise, mechano-elastic forces, etc.) in development. These predictions, along with some perspectives for future work, are also reviewed and discussed.

journal_name

Semin Cell Dev Biol

journal_title

Seminars in cell & developmental biology

authors

Alvarez-Buylla ER,Azpeitia E,Barrio R,Benítez M,Padilla-Longoria P

doi

10.1016/j.semcdb.2009.11.010

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

108-17

issue

eissn

1084-9521

issn

1096-3634

pii

S1084-9521(09)00235-3

journal_volume

pub_type

杂志文章,评审

在线工具

From ABC genes to regulatory networks, epigenetic landscapes and flower morphogenesis: making biological sense of theoretical approaches.