Abstract：
:Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation to the semicircular canals. Mice lacking NT-3 or its receptor, Trk C, show a severe reduction of spiral neurons in the basal turn of the cochlea. Mice lacking both BDNF and NT-3 or Trk B and Trk C, reportedly lose all innervation to the inner ear. These two neurotrophins and their associated receptors are necessary for the normal afferent innervation of the inner ear.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Fritzsch B,Silos-Santiago I I,Bianchi LM,Fariñas I Idoi
10.1006/scdb.1997.0144subject
Has Abstractpub_date
1997-06-01 00:00:00pages
277-284issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(97)90144-0journal_volume
8pub_type
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