Abstract：
:For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-specific cargos are considered as novel diagnostic biomarkers as well as therapeutic targets. With the advancement in high-throughput technologies on multiomics studies and improvements in bioinformatics approaches, a huge number of vesicular proteins, mRNAs, miRNAs, lipids, and metabolites have been identified, and our understanding of these complex extracellular organelles has considerably increased during these past years. In this review, we highlight EVpedia (http://evpedia.info), a community web portal for systematic analyses of prokaryotic and eukaryotic extracellular vesicles research.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Kim DK,Lee J,Simpson RJ,Lötvall J,Gho YSdoi
10.1016/j.semcdb.2015.02.005subject
Has Abstractpub_date
2015-04-01 00:00:00pages
4-7eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00032-4journal_volume
40pub_type
杂志文章,评审abstract：:Genomic instability resultant from defective DNA repair mechanisms is a fundamental hallmark of cancer. The poly(ADP-ribose) polymerase (PARP) proteins 1, 2 and 3 catalyze the polymerization of poly(ADP-ribose) and covalent attachment to proteins in a phylogenetically ancient form of protein modification. PARPs play a...
journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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doi：10.1016/j.semcdb.2005.03.006
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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pub_type： 杂志文章,评审
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abstract：:The glyoxalase system has been studied since 1913. The biochemical function of this enzymatic system is the metabolism of reactive dicarbonyl metabolites, glyoxal and methylglyoxal, to less reactive products. In the last decade research has shown that methylglyoxal is the precursor of quantitatively important damage t...
journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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abstract：:Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model o...
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abstract：:Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 198...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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