Abstract：
:Craniofacial muscles, muscles that move the eyes, control facial expression and allow food uptake and speech, have long been regarded as a variation on the general body muscle scheme. However, evidence has accumulated that the function of head muscles, their developmental anatomy and the underlying regulatory cascades are distinct. This article reviews the key aspects of craniofacial muscle and muscle stem cell formation and discusses how this differs from the trunk programme of myogenesis; we show novel RNAseq data to support this notion. We also trace the origin of head muscle in the chordate ancestors of vertebrates and discuss links with smooth-type muscle in the primitive chordate pharynx. We look out as to how the special properties of head muscle precursor and stem cells, in particular their competence to contribute to the heart, could be exploited in regenerative medicine.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Schubert FR,Singh AJ,Afoyalan O,Kioussi C,Dietrich Sdoi
10.1016/j.semcdb.2017.12.013subject
Has Abstractpub_date
2019-07-01 00:00:00pages
31-44eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30148-9journal_volume
91pub_type
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