Abstract:
:Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominant role as a guardian of the developmental clock that ensures precision of cell flow in the developing head.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Mandalos NP,Remboutsika Edoi
10.1016/j.semcdb.2016.08.035subject
Has Abstractpub_date
2017-03-01 00:00:00pages
43-49eissn
1084-9521issn
1096-3634pii
S1084-9521(16)30284-1journal_volume
63pub_type
杂志文章,评审abstract::During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina intera...
journal_title:Seminars in cell & developmental biology
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abstract::Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently b...
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abstract::The von Hippel-Lindau tumor suppressor pVHL plays a critical role in the pathogenesis of familial and sporadic clear cell carcinomas of the kidney and hemangioblastomas of the retina and central nervous system. pVHL targets the oxygen sensitive alpha subunit of hypoxia-inducible factor (HIF) for proteasomal degradatio...
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journal_title:Seminars in cell & developmental biology
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abstract::Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose ne...
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abstract::Embryonic development is a complex and highly dynamic process during which individual cells interact with one another, adopt different identities and organize themselves in three-dimensional space to generate an entire organism. Recent technical developments in genomics and high-resolution quantitative imaging are mak...
journal_title:Seminars in cell & developmental biology
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abstract::The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators of intracellular glucose sensing. By regulating target genes involved in glycolysis and lipogenesis, they mediate metabolic adaptation to changing glucose levels. As disturbed glucose h...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Human SERPINB3 and SERPINB4 are evolutionary duplicated serine/cysteine protease inhibitors. Genomic analysis indicates that these paralogous genes were encoded from independent loci arising from tandem gene duplication. Although the two molecules share 92% identity of their amino acid sequences, they are distinct in ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
abstract::The intestine has long been studied as a model for adult stem cells due to the life-long self-renewal of the intestinal epithelium through the proliferation of the adult intestinal stem cells. Recent evidence suggests that the formation of adult intestinal stem cells in mammals takes place during the thyroid hormone-d...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0277
更新日期:1999-06-01 00:00:00
abstract::Plant oils represent an energy-rich and carbon-dense group of hydrophobic compounds. These oils are not only of economic interest, but also play important, fundamental roles in plant and algal growth and development. The subcellular storage compartments of plant lipids, referred to as lipid droplets (LDs), have long b...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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doi:10.1016/j.semcdb.2015.09.005
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abstract::Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteris...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.12.022
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abstract::The Drosophila heart, also called the dorsal vessel, is a linear tube consisting of two major cell types, namely cardioblasts which serve as cardiomyocytes and pericardial cells which surround its outer surface. This organ is derived from segmental clusters of cells in the dorsal mesoderm during early embryonic develo...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Viruses have evolved strategies to evade immunity mediated by antibody and complement. Herpesviruses and coronaviruses encode IgG Fc binding proteins that inhibit IgG activity, enabling the virus or infected cell to escape antibody attack. Herpesviruses, vaccinia virus and HIV-1 have the capacity to interfere with com...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model o...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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abstract::Can plants perceive sound? And what sounds are they likely to be "listening" to? The environment of plants includes many informative sounds, produced by biotic and abiotic sources. An ability to respond to these sounds could thus have a significant adaptive value for plants. We suggest the term phytoacoustics to descr...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::How limited is the ability of stem cells to generate gametes or differentiated somatic cells? Recent outcomes of research with stem cells from both embryonic and adult origin will be discussed with particular attention to results that challenge conventional wisdom about the presence of reproductive stem cells in adult...
journal_title:Seminars in cell & developmental biology
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abstract::The sympathetic nervous system represents a critical mechanism for homoeostatic blood pressure regulation in humans. This review focuses on age-related alterations in neurocirculatory regulation in men and women by highlighting human studies that examined the relationship between muscle sympathetic nerve activity (MSN...
journal_title:Seminars in cell & developmental biology
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abstract::Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. Th...
journal_title:Seminars in cell & developmental biology
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abstract::Extracellular vesicles (EVs) act as carriers of molecular and oncogenic signatures present in subsets of tumour cells and tumour-associated stroma, and as mediators of intercellular communication. These processes likely involve cancer stem cells (CSCs). EVs represent a unique pathway of cellular export and cell-to-cel...
journal_title:Seminars in cell & developmental biology
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abstract::The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3, and ErbB4/HER4. For many years it was believed that EGFR plays a minor role in the development and progression of breast malignancies. However, recen...
journal_title:Seminars in cell & developmental biology
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