Abstract:
:Lamellipodial locomotion of fish keratocytes is one of the simplest examples of actin-based motility. In the last four decades, fruitful collaborations between experimentalists and theorists have resulted in a detailed mechanistic understanding of the self-organized lamellipodial engine powering keratocyte motility. Here we review the mechanical mechanisms underlying keratocyte migration, highlighting the interplay between modeling and experiments that led to insights regarding the dynamics of actin network organization, cell shape, and self-polarization. We discuss how to apply lessons learnt from keratocytes to understand cell migration in more complex, physiological contexts.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Mogilner A,Barnhart EL,Keren Kdoi
10.1016/j.semcdb.2019.10.019subject
Has Abstractpub_date
2020-04-01 00:00:00pages
143-151eissn
1084-9521issn
1096-3634pii
S1084-9521(19)30036-9journal_volume
100pub_type
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