Abstract:
:A number of proteins produced by certain bacteria and plants are potently toxic to mammalian cells. This toxicity results from their ability to catalytically modify macromolecules that are required for essential cellular functions such as vesicular trafficking, cytoskeletal assembly, signalling or protein synthesis. To reach their targets, these proteins bind specific surface receptors before endocytosis and translocation across an internal membrane. The surface receptors exploited by different toxins include a range of proteins and lipids. Here we focus on specific glycosphingolipid receptors and two well-characterised subsets of toxins that exploit them for surface binding, intracellular trafficking, and signalling events.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Smith DC,Lord JM,Roberts LM,Johannes Ldoi
10.1016/j.semcdb.2004.03.005subject
Has Abstractpub_date
2004-08-01 00:00:00pages
397-408issue
4eissn
1084-9521issn
1096-3634pii
S1084-9521(04)00035-7journal_volume
15pub_type
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