Dictyostelium as a model for human lysosomal and trafficking diseases.

abstract：:Axonal projections between two populations of neurons, which preserve neighborhood relationships, are called topographic. They are ubiquitous in the brain. The development of the retinotectal projection, mapping the retinal output onto the roof of the midbrain, has been studied for decades as a model system. The rigid...

journal_title：Seminars in cell & developmental biology

authors： Weth F,Fiederling F,Gebhardt C,Bastmeyer M

更新日期：2014-11-01 00:00:00

abstract：:During development, epithelial cells in some tissues acquire a polarity orthogonal to their apical-basal axis. This polarity, referred to as planar cell polarity (PCP), or tissue polarity, is essential for the normal physiological function of many epithelia. Early studies of PCP focused on insect epithelia (Lawrence, ...

journal_title：Seminars in cell & developmental biology

authors： Axelrod JD

更新日期：2009-10-01 00:00:00

abstract：:Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...

journal_title：Seminars in cell & developmental biology

authors： Nie P,Vartak A,Li YM

更新日期：2020-09-01 00:00:00

abstract：:Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions...

journal_title：Seminars in cell & developmental biology

authors： Kim M,Bjorke B,Mastick GS

更新日期：2019-01-01 00:00:00

abstract：:Both types of Drosophila egg chamber germ cells, i.e. oocyte and nurse cells, have to control their nucleus positions in order to produce a viable gamete. Interestingly, while actin microfilaments are crucial to position the nuclei in nurse cells, these are the microtubules that are important for oocyte nucleus to mig...

journal_title：Seminars in cell & developmental biology

authors： Bernard F,Lepesant JA,Guichet A

更新日期：2018-10-01 00:00:00

abstract：:Anuran amphibians can regenerate the retina through differentiation of stem cells in the ciliary marginal zone and through transdifferentiation of the retinal pigmented epithelium. By contrast, the regeneration of the lens has been demonstrated only in larvae of species belonging to the Xenopus genus, where the lens r...

journal_title：Seminars in cell & developmental biology

authors： Filoni S

更新日期：2009-07-01 00:00:00

abstract：:In the recent years several papers and some reviews have dealt with characterization, localization and influence on the precipitation of calcium carbonate, of the organic matrix from scleractinian corals. In fact, it has been well established that coral calcification is a biological controlled process orchestrated in ...

journal_title：Seminars in cell & developmental biology

authors： Falini G,Fermani S,Goffredo S

更新日期：2015-10-01 00:00:00

abstract：:The glyoxalase system consists of glyoxalase I and glyoxalase II. Glyoxalase I catalyzes the conversion of methylglyoxal (CH(3)COCHO), a metabolite derived from glycolysis, with glutathione to S-D-lactoylglutathione, while glyoxalase II hydrolyses this glutathione thiolester to D-lactic acid and glutathione. Since met...

journal_title：Seminars in cell & developmental biology

authors： Inoue Y,Maeta K,Nomura W

更新日期：2011-05-01 00:00:00

abstract：:Genomic instability resultant from defective DNA repair mechanisms is a fundamental hallmark of cancer. The poly(ADP-ribose) polymerase (PARP) proteins 1, 2 and 3 catalyze the polymerization of poly(ADP-ribose) and covalent attachment to proteins in a phylogenetically ancient form of protein modification. PARPs play a...

journal_title：Seminars in cell & developmental biology

authors： Dulaney C,Marcrom S,Stanley J,Yang ES

更新日期：2017-03-01 00:00:00

abstract：:Cells maintain a cholesterol gradient across the secretory system, with the lowest concentrations in the endoplasmic reticulum (ER) and the highest in the plasma membrane (PM). Cholesterol is also heterogeneously distributed in the endocytic pathway. Little is known about how this heterogeneous distribution of cholest...

journal_title：Seminars in cell & developmental biology

authors： Prinz W

更新日期：2002-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a neurological condition which affects a large number of individuals worldwide, across all ages. It can lead to major physical, cognitive and psychological impairment, and represents a considerable health cost burden. TBI is a heterogeneous condition and there has been intense effort ov...

journal_title：Seminars in cell & developmental biology

authors： Nessel I,Michael-Titus AT

更新日期：2020-10-06 00:00:00

abstract：:Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over dis...

journal_title：Seminars in cell & developmental biology

authors： Niethammer P

更新日期：2018-08-01 00:00:00

abstract：:Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin genes encode at least 7 characteristic functional domains which are combined in a modular fashion into multiple isoforms, and which ar...

journal_title：Seminars in cell & developmental biology

authors： Voelzmann A,Liew YT,Qu Y,Hahn I,Melero C,Sánchez-Soriano N,Prokop A

更新日期：2017-09-01 00:00:00

abstract：:Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a hig...

journal_title：Seminars in cell & developmental biology

authors： Burr R,Espenshade PJ

更新日期：2018-09-01 00:00:00

abstract：:Conrad Waddington published an influential model for evolution in his 1942 paper, Canalization of Development and Inheritance of Acquired Characters. In this classic, albeit controversial, paper, he proposed that an unknown mechanism exists that conceals phenotypic variation until the organism is stressed. Recent stud...

journal_title：Seminars in cell & developmental biology

authors： Ruden DM,Garfinkel MD,Sollars VE,Lu X

更新日期：2003-10-01 00:00:00

abstract：:One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through d...

journal_title：Seminars in cell & developmental biology

authors： Lee YL,Burke B

更新日期：2018-10-01 00:00:00

abstract：:Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a convergent body of biochemical and molecular genetic studies have confirmed their structural and functional relationship as an integrative hub through which regulatory information conveyed by signal activated transcription fact...

journal_title：Seminars in cell & developmental biology

authors： Spaeth JM,Kim NH,Boyer TG

更新日期：2011-09-01 00:00:00

abstract：:Gene duplication events produce both perfect and imperfect copies of genes. Perfect copies are said to be functionally redundant when knockout of one gene produces no 'scoreable', phenotypic effects. Preserving identical, duplicate copies of genes is problematic as all copies are prone to accumulate neutral mutations ...

journal_title：Seminars in cell & developmental biology

authors： Krakauer DC,Nowak MA

更新日期：1999-10-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is an intracellular compartment devoted to the synthesis, segregation and folding of soluble and membrane secretory proteins. Some mutations in these proteins lead to their incorrect or incomplete folding in the ER. The ER has a quality control system which detects misfolded proteins and...

journal_title：Seminars in cell & developmental biology

authors： Chevet E,Jakob CA,Thomas DY,Bergeron JJ

更新日期：1999-10-01 00:00:00

abstract：:The identification of extensive genetic heterogeneity in human breast carcinomas poses a significant challenge for designing effective treatment regimens. Significant genomic evolution often occurs during breast cancer progression, creating variability within primary tumors as well as between the primary carcinoma and...

journal_title：Seminars in cell & developmental biology

authors： Ellsworth RE,Blackburn HL,Shriver CD,Soon-Shiong P,Ellsworth DL

更新日期：2017-04-01 00:00:00

abstract：:The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...

journal_title：Seminars in cell & developmental biology

authors： Oda A,Eto K

更新日期：2013-04-01 00:00:00

abstract：:Freshwater planarians are well known for their remarkable plasticity and regenerative capabilities. Most studies of planarian regeneration have specifically examined regeneration after transverse or longitudinal sectioning or during homeostasis in intact adults. However, tissue transplantation, first performed over a ...

journal_title：Seminars in cell & developmental biology

authors： Rojo-Laguna JI,Garcia-Cabot S,Saló E

更新日期：2019-03-01 00:00:00

abstract：:The Notch pathway is one of the major signaling pathways required for proper development in metazoans. Notch activity is regulated at numerous levels, and increasing evidence reveals the importance of "protein glycosylation" (modification of Notch receptors with sugars) for its regulation. In this review we summarize ...

journal_title：Seminars in cell & developmental biology

authors： Takeuchi H,Haltiwanger RS

更新日期：2010-08-01 00:00:00

abstract：:Cellular morphogenesis is a complex process and molecular studies in the last few decades have amassed a large amount of information that is difficult to grasp in any completeness. Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulato...

journal_title：Seminars in cell & developmental biology

authors： Wedlich-Soldner R,Li R

更新日期：2008-06-01 00:00:00

abstract：:During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to es...

journal_title：Seminars in cell & developmental biology

authors： Briscoe J,Ericson J

更新日期：1999-06-01 00:00:00

abstract：:Research using Xenopus laevis has made enormous contributions to our understanding of vertebrate development, control of the eukaryotic cell cycle and the cytoskeleton. One limitation, however, has been the lack of systematic genetic studies in Xenopus to complement molecular and cell biological investigations. Work w...

journal_title：Seminars in cell & developmental biology

authors： Carruthers S,Stemple DL

更新日期：2006-02-01 00:00:00

abstract：:The hallmarks of cancer include multiple alterations in the physiological processes occurring in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These aberrant behaviors are due to genetic and epigenetic changes that affect signaling pathways controlling cancer cells, as well as t...

journal_title：Seminars in cell & developmental biology

authors： Rehman M,Tamagnone L

更新日期：2013-03-01 00:00:00

abstract：:Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trispho...

journal_title：Seminars in cell & developmental biology

authors： Zhang X,Majerus PW

更新日期：1998-04-01 00:00:00

abstract：:Newly synthesized polypeptide chains must fold and assemble into unique three-dimensional structures in order to become functionally active. In many cases productive folding depends on assistance from molecular chaperones, which act in preventing off-pathway reactions during folding that lead to aggregation. The inher...

journal_title：Seminars in cell & developmental biology

authors： Agashe VR,Hartl FU

更新日期：2000-02-01 00:00:00

abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...

journal_title：Seminars in cell & developmental biology

authors： Campàs O

更新日期：2016-07-01 00:00:00