Abstract：
:Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions remain poorly understood. Here, we review recent evidence of motor neuron positioning mechanisms, highlighting situations in which motor neuron cell bodies can migrate, and experiments that show that their migration is regulated by axon guidance cues. The view that emerges is that motor neurons are actively trapped or restricted in static positions, as the cells balance a push in the dorsal direction by repulsive Slit/Robo cues and a pull in the ventral direction by attractive Netrin-1/DCC cues. These new functions of guidance cues are necessary fine-tuning to set up patterns of motor neurons at their proper positions in the neural tube during embryogenesis.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Kim M,Bjorke B,Mastick GSdoi
10.1016/j.semcdb.2017.11.016subject
Has Abstractpub_date
2019-01-01 00:00:00pages
78-83eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30465-2journal_volume
85pub_type
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