Abstract：
:One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through dermal differentiation in nematodes, to muscle and neuronal development in vertebrates. Each of these processes involves oftentimes dramatic relocation of the nucleus within the cell. During the last decade it has become apparent that the nuclear periphery represents a nexus of cytoskeletal interactions that are involved not only in nuclear movement but also in the distribution and dissemination of mechanical forces throughout the cell. Nucleocytoskeletal coupling is mediated in large part by SUN- and KASH-domain proteins of the nuclear membranes, that together assemble to form LINC (Linker of the Nucleoskeleton and Cytoskeleton) complexes. In this review we will describe how the LINC complex repertoire contributes to nuclear positioning and chromosome dynamics in a variety of cellular contexts.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Lee YL,Burke Bdoi
10.1016/j.semcdb.2017.11.008subject
Has Abstractpub_date
2018-10-01 00:00:00pages
67-76eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30455-Xjournal_volume
82pub_type
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