Embryonic mammary gland development.

abstract：:Embryonic patterning of the mouse during gastrulation and early organogenesis engenders the specification of anterior versus posterior structures and body laterality by the interaction of signalling and modulating activities. A group of cells in the mouse gastrula, characterised by the expression of a repertoire of "o...

journal_title：Seminars in cell & developmental biology

authors： Robb L,Tam PP

更新日期：2004-10-01 00:00:00

abstract：:Eph receptor tyrosine kinases mediate cell-cell communication by interacting with ephrin ligands residing on adjacent cell surfaces. In doing so, these juxtamembrane signaling complexes provide important contextual information about the cellular microenvironment that helps orchestrate tissue morphogenesis and maintain...

journal_title：Seminars in cell & developmental biology

authors： Lin S,Wang B,Getsios S

更新日期：2012-02-01 00:00:00

abstract：:As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become incr...

journal_title：Seminars in cell & developmental biology

authors： Wassing IE,Esashi F

更新日期：2020-09-13 00:00:00

abstract：:Traumatic brain injury (TBI) is a neurological condition which affects a large number of individuals worldwide, across all ages. It can lead to major physical, cognitive and psychological impairment, and represents a considerable health cost burden. TBI is a heterogeneous condition and there has been intense effort ov...

journal_title：Seminars in cell & developmental biology

authors： Nessel I,Michael-Titus AT

更新日期：2020-10-06 00:00:00

abstract：:In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a family of peptide growth factors that activate the EGF receptors, and that the EGF/EGF receptor signaling pathway plays important roles in...

journal_title：Seminars in cell & developmental biology

authors： Zeng F,Harris RC

更新日期：2014-04-01 00:00:00

abstract：:Vitamin A and its derivatives, the retinoids, have been implicated as important signaling molecules in vertebrate development, primarily due to numerous gain-of-function experiments involving treatment of embryos with exogenous retinoic acid. Collectively, the results from these experiments suggested that retinoids we...

journal_title：Seminars in cell & developmental biology

authors： Blumberg B

更新日期：1997-08-01 00:00:00

abstract：:During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilob...

journal_title：Seminars in cell & developmental biology

authors： Heisenberg CP,Tada M

更新日期：2002-12-01 00:00:00

abstract：:The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart diseases. Uncovering such a long-awaited therapy is still extremely challenging in the current settin...

journal_title：Seminars in cell & developmental biology

authors： Witman N,Zhou C,Grote Beverborg N,Sahara M,Chien KR

更新日期：2020-04-01 00:00:00

abstract：:Freshwater planarians are well known for their remarkable plasticity and regenerative capabilities. Most studies of planarian regeneration have specifically examined regeneration after transverse or longitudinal sectioning or during homeostasis in intact adults. However, tissue transplantation, first performed over a ...

journal_title：Seminars in cell & developmental biology

authors： Rojo-Laguna JI,Garcia-Cabot S,Saló E

更新日期：2019-03-01 00:00:00

abstract：:Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-...

journal_title：Seminars in cell & developmental biology

authors： Diaz-delCastillo M,Chantry AD,Lawson MA,Heegaard AM

更新日期：2020-11-03 00:00:00

abstract：:Cellular morphogenesis is a complex process and molecular studies in the last few decades have amassed a large amount of information that is difficult to grasp in any completeness. Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulato...

journal_title：Seminars in cell & developmental biology

authors： Wedlich-Soldner R,Li R

更新日期：2008-06-01 00:00:00

abstract：:Pollen tubes extend rapidly in an oscillatory manner by the extreme form of polarized growth, tip growth, and provide an exciting system for studying the spatiotemporal control of polarized cell growth. The Rho-family ROP GTPase is a key signaling molecule in this growth control and is periodically activated at the ap...

journal_title：Seminars in cell & developmental biology

authors： Qin Y,Yang Z

更新日期：2011-10-01 00:00:00

abstract：:Axonal projections between two populations of neurons, which preserve neighborhood relationships, are called topographic. They are ubiquitous in the brain. The development of the retinotectal projection, mapping the retinal output onto the roof of the midbrain, has been studied for decades as a model system. The rigid...

journal_title：Seminars in cell & developmental biology

authors： Weth F,Fiederling F,Gebhardt C,Bastmeyer M

更新日期：2014-11-01 00:00:00

abstract：:Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinat...

journal_title：Seminars in cell & developmental biology

authors： Depino AM

更新日期：2018-05-01 00:00:00

abstract：:Glucose-induced insulin secretion is pulsatile. Glucose metabolism generates oscillations in the ATP/ADP ratio which lead to opening and closing of ATP-sensitive K(+)-channels producing subsequent oscillations in membrane potential, cytoplasmic calcium and insulin release. Metabolic signals derived from glucose can al...

journal_title：Seminars in cell & developmental biology

authors： Deeney JT,Prentki M,Corkey BE

更新日期：2000-08-01 00:00:00

abstract：:The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive third degree burn...

journal_title：Seminars in cell & developmental biology

authors： Barrandon Y,Grasset N,Zaffalon A,Gorostidi F,Claudinot S,Droz-Georget SL,Nanba D,Rochat A

更新日期：2012-10-01 00:00:00

abstract：:Angiosperms display a huge variety of floral forms. The development of the ABC-model for floral organ identity, almost 20 years ago, has created an excellent basis for comparative floral development (evo-devo) studies. These have resulted in an increasingly more detailed understanding of the molecular control circuitr...

journal_title：Seminars in cell & developmental biology

authors： Rijpkema AS,Vandenbussche M,Koes R,Heijmans K,Gerats T

更新日期：2010-02-01 00:00:00

abstract：:Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of...

journal_title：Seminars in cell & developmental biology

authors： Salick MR,Lubeck E,Riesselman A,Kaykas A

更新日期：2020-07-09 00:00:00

abstract：:The actin cytoskeleton is critically involved in a variety of cell functions. The Arp2/3 complex mediates branching of filamentous actin. The members of the Wiskott-Aldrich syndrome protein (WASP) family are major regulators of the complex. As such, the family proteins are also involved in numerous aspects of cell bio...

journal_title：Seminars in cell & developmental biology

authors： Oda A,Eto K

更新日期：2013-04-01 00:00:00

abstract：:Both types of Drosophila egg chamber germ cells, i.e. oocyte and nurse cells, have to control their nucleus positions in order to produce a viable gamete. Interestingly, while actin microfilaments are crucial to position the nuclei in nurse cells, these are the microtubules that are important for oocyte nucleus to mig...

journal_title：Seminars in cell & developmental biology

authors： Bernard F,Lepesant JA,Guichet A

更新日期：2018-10-01 00:00:00

abstract：:The identification of extensive genetic heterogeneity in human breast carcinomas poses a significant challenge for designing effective treatment regimens. Significant genomic evolution often occurs during breast cancer progression, creating variability within primary tumors as well as between the primary carcinoma and...

journal_title：Seminars in cell & developmental biology

authors： Ellsworth RE,Blackburn HL,Shriver CD,Soon-Shiong P,Ellsworth DL

更新日期：2017-04-01 00:00:00

abstract：:Pigment cells serve a variety of important uses across the animal kingdom, and in many species can change and regenerate throughout the lifetime of the organism. The functions of these cells, as well as their origins in both embryonic development and adult regeneration, are not fully understood. Here, we review advanc...

journal_title：Seminars in cell & developmental biology

authors： Lindsay-Mosher N,Pearson BJ

更新日期：2019-03-01 00:00:00

abstract：:The integration of living cells together with silicon field-effect devices challenges a new generation of biosensors and bioelectronic devices. Cells are representing highly organised complex systems, optimised by millions of years of evolution and offering a broad spectrum of bioanalytical receptor "tools" such as en...

journal_title：Seminars in cell & developmental biology

authors： Poghossian A,Ingebrandt S,Offenhäusser A,Schöning MJ

更新日期：2009-02-01 00:00:00

abstract：:During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina intera...

journal_title：Seminars in cell & developmental biology

authors： Layer PG,Rothermel A,Willbold E

更新日期：1998-06-01 00:00:00

abstract：:Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model o...

journal_title：Seminars in cell & developmental biology

authors： Sahu S,Dattani A,Aboobaker AA

更新日期：2017-10-01 00:00:00

abstract：:The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and ben...

journal_title：Seminars in cell & developmental biology

authors： Hou L,Srivastava Y,Jauch R

更新日期：2017-03-01 00:00:00

abstract：:Given the large socio-economic burden of cancer, there is an urgent need for in vivo animal cancer models that can provide a rationale for personalised therapeutic regimens that are translatable to the clinic. Recent developments in establishing mouse models that closely resemble human lung cancers involve the applica...

journal_title：Seminars in cell & developmental biology

authors： Hayes SA,Hudson AL,Clarke SJ,Molloy MP,Howell VM

更新日期：2014-03-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that allow adaptation to hypoxic environments. HIFs function in the cellular response to stress: metabolic, hypoxic, or inflammatory. Metabolic changes occur during tumorigenesis that are, in part, under hypoxia and HIF regulation. Additionall...

journal_title：Seminars in cell & developmental biology

authors： Shay JE,Celeste Simon M

更新日期：2012-06-01 00:00:00

abstract：:The von Hippel-Lindau tumor suppressor pVHL plays a critical role in the pathogenesis of familial and sporadic clear cell carcinomas of the kidney and hemangioblastomas of the retina and central nervous system. pVHL targets the oxygen sensitive alpha subunit of hypoxia-inducible factor (HIF) for proteasomal degradatio...

journal_title：Seminars in cell & developmental biology

authors： Haase VH

更新日期：2005-08-01 00:00:00

abstract：:The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...

journal_title：Seminars in cell & developmental biology

authors： Claude-Taupin A,Bissa B,Jia J,Gu Y,Deretic V

更新日期：2018-11-01 00:00:00