Abstract:
:Embryonic patterning of the mouse during gastrulation and early organogenesis engenders the specification of anterior versus posterior structures and body laterality by the interaction of signalling and modulating activities. A group of cells in the mouse gastrula, characterised by the expression of a repertoire of "organiser" genes, acts as a source and the conduit for allocation of the axial mesoderm, floor plate and definitive endoderm. The organiser and its derivatives provide the antagonistic activity that modulates WNT and TGFbeta signalling. Recent findings show that the organiser activity is augmented by morphogenetic activity of the extraembryonic and embryonic endoderm, suggesting embryonic patterning is not solely the function of the organiser.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Robb L,Tam PPdoi
10.1016/j.semcdb.2004.04.005subject
Has Abstractpub_date
2004-10-01 00:00:00pages
543-54issue
5eissn
1084-9521issn
1096-3634pii
S1084-9521(04)00041-2journal_volume
15pub_type
杂志文章,评审abstract::The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing patches of sensory epithelia, each with a specialised function. The ear contains many different...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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