Abstract：
:Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and contrast enhancement during a prolonged asymptomatic phase, prior to when it "collapses" with accelerated synovitis and joint erosion. This PLN collapse is associated with adjacent knee flare, decreases in PLN volume and contrast enhancement, lymphatic pulse and pumping pressure, and an increase in PLN pressure. Currently, it is known that PLN collapse is accompanied by a translocation of B cells from the follicles to the sinuses, effectively clogging the lymphatic sinuses of the PLN, and that B cell depletion therapy ameliorates arthritic flare by eliminating these B cells and restoring passive lymphatic flow from inflamed joints. Here we review the technological advances that have launched this area of research, describe future directions to help elucidate the potential mechanism of PLN collapse, and speculate on clinical translation towards new diagnostics and therapies for RA.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Bouta EM,Li J,Ju Y,Brown EB,Ritchlin CT,Xing L,Schwarz EMdoi
10.1016/j.semcdb.2015.01.001subject
Has Abstractpub_date
2015-02-01 00:00:00pages
90-7eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00002-6journal_volume
38pub_type
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