Abstract：
:Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model organisms have relatively short lifespans. Here we consider the use of planarians, with an immortal life-history that is able to entirely avoid the ageing process. These animals are capable of profound feats of regeneration fueled by a population of adult stem cells called neoblasts. These cells are capable of indefinite self-renewal that has underpinned the evolution of animals that reproduce only by fission, having disposed of the germline, and must therefore be somatically immortal and avoid the ageing process. How they do this is only now starting to be understood. Here we suggest that the evidence so far supports the hypothesis that the lack of ageing is an emergent property of both being highly regenerative and the evolution of highly effective mechanisms for ensuring genome stability in the neoblast stem cell population. The details of these mechanisms could prove to be very informative in understanding how the causes of ageing can be avoided, slowed or even reversed.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Sahu S,Dattani A,Aboobaker AAdoi
10.1016/j.semcdb.2017.08.028subject
Has Abstractpub_date
2017-10-01 00:00:00pages
108-121eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30255-0journal_volume
70pub_type
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