Abstract：
:With the arrival of atomic force microscopy (AFM) about thirty years ago, this new imaging tool opened up a new area for the exploration of biological samples, ranging from the tissue and cellular level down to the supramolecular scale. Commercial instruments of this new imaging technique began to appear in the five years following its discovery in 1986 by Binnig, Quate & Gerber. From that point onwards the AFM has attracted many liver biologists, and the number of publications describing structure-function relationships on the diverse set of liver cells has grown steadily ever since. It is therefore timely to reflect on the achievements of AFM in disclosing the cellular architecture of hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, stellate cells and liver-associated natural killer cells. In this thematic paper, we present new data and provide an in-depth overview of the current AFM literature on liver cell biology. We furthermore include a future outlook on how this scanning probe imaging tool and its latest developments can contribute to clarify various structural and functional aspects of cells in liver health and disease.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Braet F,Taatjes DJ,Wisse Edoi
10.1016/j.semcdb.2017.07.001subject
Has Abstractpub_date
2018-01-01 00:00:00pages
13-30eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30325-7journal_volume
73pub_type
杂志文章,评审abstract：:Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over dis...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2017.07.038
更新日期：2018-08-01 00:00:00
abstract：:The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to b...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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abstract：:The pharyngeal arches form the face and neck of the developing embryo. The pharyngeal tissue is divided into distinct arches by the formation of clefts and pouches in between the arches. These clefts and pouches form at the juxtaposition between the ectoderm and endoderm and develop into a variety of essential structu...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2010.01.022
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abstract：:Ascidians are urochordates, marine invertebrates with non-feeding motile chordate tadpole larvae, except in the family Molgulidae. Urodele, or tailed, Molgulids have typical ascidian chordate tadpole larvae possessing tails with muscle cells, a notochord, and a dorsal hollow nerve cord. In contrast, anural (or tail-le...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章
doi：10.1006/scdb.2000.0195
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abstract：:Cholesterol is highly enriched in the brain compared to other tissues. Essentially all cholesterol in the brain is synthesized endogenously since plasma lipoproteins are unable to cross the blood-brain barrier. Cholesterol is transported within the central nervous system in the form of apolipoprotein E-containing lipo...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2005.01.005
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abstract：:Formation and maturation of a functional vascular network is a process called angiogenesis. This is a crucial biological event in all vertebrates. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Reactive oxygen species (ROS) and...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
abstract：:The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of vi...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2015.10.014
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abstract：:During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina intera...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.1998.0234
更新日期：1998-06-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.1999.0337
更新日期：1999-10-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2004.04.005
更新日期：2004-10-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2020.02.014
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2016.08.025
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2020.08.009
更新日期：2020-09-07 00:00:00
abstract：:The role of the tight junctions (TJ) in controlling paracellular traffic of ions and molecules, through the regulation of claudin proteins, is now established. However, it has also become increasingly evident that claudin proteins, as integral components of the TJs, play crucial role in maintaining the cell-cell integ...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2015.05.001
更新日期：2015-06-01 00:00:00
abstract：:The Drosophila heart, also called the dorsal vessel, is a linear tube consisting of two major cell types, namely cardioblasts which serve as cardiomyocytes and pericardial cells which surround its outer surface. This organ is derived from segmental clusters of cells in the dorsal mesoderm during early embryonic develo...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.1998.0279
更新日期：1999-02-01 00:00:00
abstract：:Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a convergent body of biochemical and molecular genetic studies have confirmed their structural and functional relationship as an integrative hub through which regulatory information conveyed by signal activated transcription fact...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.1999.0298
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abstract：:Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation t...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章
doi：10.1006/scdb.1997.0144
更新日期：1997-06-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2002-06-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.1998.0242
更新日期：1998-06-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：:The post-translational modification of proteins by covalent attachment of ubiquitin targets these proteins for degradation by the proteasome. An astounding number of proteins are involved in ubiquitination and deubiquitination of proteins. The pathways are combinatorial, and selectivity of proteolysis will depend stro...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1006/scdb.2000.0164
更新日期：2000-06-01 00:00:00
abstract：:Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently b...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2011.11.003
更新日期：2012-04-01 00:00:00
abstract：:Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells. It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and glutathione synthetase, and its level is well regulated in response to redox change. Accumulating evidence suggests that GSH may play im...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2012.03.017
更新日期：2012-09-01 00:00:00
abstract：:Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2018.02.022
更新日期：2018-11-01 00:00:00
abstract：:Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominan...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2016.08.035
更新日期：2017-03-01 00:00:00
