Cholesterol homeostasis in neurons and glial cells.

abstract：:CLEs are small non-cell autonomous signalling peptides that regulate cell division rate and orientation in a variety of developmental contexts. Recent years have generated a huge amount of research on CLE function across land plants, characterising their role across the whole plant; they control stem cell division in ...

journal_title：Seminars in cell & developmental biology

authors： Whitewoods CD

更新日期：2020-05-20 00:00:00

abstract：:The urinary collecting system is derived from an epithelial protrusion arising from the Wolffian duct called the ureteric bud (UB) by the signal from its inductive tissue, metanephric mesenchyme (MM). Targeted gene mutation studies have shown that several transcription factors and MM-secreted glial cell line-derived n...

journal_title：Seminars in cell & developmental biology

authors： Sakurai H

更新日期：2003-08-01 00:00:00

abstract：:Centrioles and basal bodies are MT based structures that present a highly conserved ninefold symmetry. Centrioles can be found at the core of the centrosome where they participate in PCM recruitment and organization, contributing to cytoplasmic MT nucleation. Basal bodies are normally located closely to the plasma mem...

journal_title：Seminars in cell & developmental biology

authors： Gogendeau D,Basto R

更新日期：2010-04-01 00:00:00

abstract：:The notion of feedback is fundamental for understanding signal transduction networks. Feedback loops attenuate or amplify signals, change the network dynamics and modify the input-output relationships between the signal and the target. Negative feedback provides robustness to noise and adaptation to perturbations, but...

journal_title：Seminars in cell & developmental biology

authors： Nguyen LK,Kholodenko BN

更新日期：2016-02-01 00:00:00

abstract：:The endocytotic machinery imports, transports and exports receptors and associated molecules between the plasma membrane and various cytoplasmic chambers resulting in selective recycling, degradation, or secretion of molecules and signaling complexes. Trafficking of receptors, growth factors, nutrients, cytokines, int...

journal_title：Seminars in cell & developmental biology

authors： Mitra S,Cheng KW,Mills GB

更新日期：2011-02-01 00:00:00

abstract：:Regulation of Notch signaling is critical to development and maintenance of most eukaryotic organisms. The Notch receptors and ligands are integral membrane proteins and direct cell-cell interactions are needed to activate signaling. Ligand-expressing cells activate Notch signaling through an unusual mechanism involvi...

journal_title：Seminars in cell & developmental biology

authors： Musse AA,Meloty-Kapella L,Weinmaster G

更新日期：2012-06-01 00:00:00

abstract：:The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesod...

journal_title：Seminars in cell & developmental biology

authors： Davidson AJ,Lewis P,Przepiorski A,Sander V

更新日期：2019-07-01 00:00:00

abstract：:Biological tubes are a prevalent structural design across living organisms. They provide essential functions during the development and adult life of an organism. Increasing progress has been made recently in delineating the cellular and molecular mechanisms underlying tubulogenesis. This review aims to introduce asci...

journal_title：Seminars in cell & developmental biology

authors： Denker E,Jiang D

更新日期：2012-05-01 00:00:00

abstract：:Skeletal muscle cells possess a unique cellular architecture designed to fulfill their contractile function. Muscle cells (also known as myofibers) result from the fusion of hundreds of myoblasts and grow into a fiber of several centimeters in length. Cellular structures gradually become organized during muscle develo...

journal_title：Seminars in cell & developmental biology

authors： Roman W,Gomes ER

更新日期：2018-10-01 00:00:00

abstract：:During development cranial neural crest cells (NCCs) display a striking transition from collective to single-cell migration, but the mechanisms enabling individual NCCs to separate from the neural crest tissue are still incompletely understood. In this study we have employed atomic force microscopy (AFM) to investigat...

journal_title：Seminars in cell & developmental biology

authors： Blaue C,Kashef J,Franz CM

更新日期：2018-01-01 00:00:00

abstract：:The post-translational modification of proteins by covalent attachment of ubiquitin targets these proteins for degradation by the proteasome. An astounding number of proteins are involved in ubiquitination and deubiquitination of proteins. The pathways are combinatorial, and selectivity of proteolysis will depend stro...

journal_title：Seminars in cell & developmental biology

authors： Wilkinson KD

更新日期：2000-06-01 00:00:00

abstract：:Large-scale identification of elements associated with gene expression revealed that many of them are located extremely far from gene transcriptional start sites. We review here the growing evidence that show that distal cis-acting elements provide key instructions to genes, as genetic variation affecting them is grow...

journal_title：Seminars in cell & developmental biology

authors： Spitz F

更新日期：2016-09-01 00:00:00

abstract：:The developmental processes that give rise to the animal body plan are exceedingly complex. Model systems such as Drosophila melanogaster have yielded profound insight into roles of conserved genes and genetic pathways in development. Drosophila development begins with the formation of sperm and eggs, and proceeds thr...

journal_title：Seminars in cell & developmental biology

authors： Mason DA,Goldfarb DS

更新日期：2009-07-01 00:00:00

abstract：:Autophagy, an evolutional conserved lysosomal degradation process, has been implicated to play an important role in cellular defense against a variety of microbial infection. Interestingly, numerous studies found that some pathogens, especially positive-single-strand RNA viruses, actually hijacked autophagy machinery ...

journal_title：Seminars in cell & developmental biology

authors： Huang L,Yue J

更新日期：2020-05-01 00:00:00

abstract：:In order for a successful pregnancy to occur, the embryo must attach to the luminal epithelial cells and invade into the stroma. Then, the surrounding stromal cells need to undergo decidualization in order to establish the vasculature necessary for survival of the embryo. These events in early pregnancy are tightly re...

journal_title：Seminars in cell & developmental biology

authors： Franco HL,Jeong JW,Tsai SY,Lydon JP,DeMayo FJ

更新日期：2008-04-01 00:00:00

abstract：:Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts,...

journal_title：Seminars in cell & developmental biology

authors： Samudyata,Castelo-Branco G,Bonetti A

更新日期：2018-07-01 00:00:00

abstract：:Complement and dendritic cells (DCs) share many functional features that drive the outcome of immune-inflammatory processes. Both have a sentinel function, acting as danger sensors specialized for a rapid, comprehensive and selective action against potential threats without damaging the healthy host cells. But while c...

journal_title：Seminars in cell & developmental biology

authors： Luque A,Serrano I,Aran JM

更新日期：2019-01-01 00:00:00

abstract：:Phytochromes in harmony with blue light photoreceptors play a major role in controlling plant growth and development from germination to seed maturation. Light absorption by phytochromes triggers a signaling cascade, phototransduction, which culminates in regulated gene expression. A major regulatory step at the cellu...

journal_title：Seminars in cell & developmental biology

authors： Nagy F,Kircher S,Schäfer E

更新日期：2000-12-01 00:00:00

abstract：:The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned ...

journal_title：Seminars in cell & developmental biology

authors： Ebnet K,Kummer D,Steinbacher T,Singh A,Nakayama M,Matis M

更新日期：2018-09-01 00:00:00

abstract：:Viruses are obligate intracellular parasites and have to use the host cell machinery for their replication. Many viruses are able to divert different parts of this machinery to preferentially enhance virus replication at the expense of the cell. The mechanisms by which different viruses do this have, over the years, g...

journal_title：Seminars in cell & developmental biology

authors： Hammarskjöld ML

更新日期：1997-02-01 00:00:00

abstract：:During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to es...

journal_title：Seminars in cell & developmental biology

authors： Briscoe J,Ericson J

更新日期：1999-06-01 00:00:00

abstract：:Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction. A population of stem and progenitor cells known as undifferentiated spermatogonia enables continual spermatogenesis throughout life. A complex transcriptional netw...

journal_title：Seminars in cell & developmental biology

authors： Legrand JMD,Hobbs RM

更新日期：2018-07-01 00:00:00

abstract：:By the development of information theory in 1948 by Claude Shannon to address the problems in the field of data storage and data communication over (noisy) communication channel, it has been successfully applied in many other research areas such as bioinformatics and systems biology. In this manuscript, we attempt to ...

journal_title：Seminars in cell & developmental biology

authors： Mousavian Z,Díaz J,Masoudi-Nejad A

更新日期：2016-03-01 00:00:00

abstract：:Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-...

journal_title：Seminars in cell & developmental biology

authors： Diaz-delCastillo M,Chantry AD,Lawson MA,Heegaard AM

更新日期：2020-11-03 00:00:00

abstract：:Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominan...

journal_title：Seminars in cell & developmental biology

authors： Mandalos NP,Remboutsika E

更新日期：2017-03-01 00:00:00

abstract：:Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, ...

journal_title：Seminars in cell & developmental biology

authors： Alculumbre S,Raieli S,Hoffmann C,Chelbi R,Danlos FX,Soumelis V

更新日期：2019-02-01 00:00:00

abstract：:The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under...

journal_title：Seminars in cell & developmental biology

authors： Biggins JS,Royer C,Watanabe T,Srinivas S

更新日期：2015-12-01 00:00:00

abstract：:The intestine has long been studied as a model for adult stem cells due to the life-long self-renewal of the intestinal epithelium through the proliferation of the adult intestinal stem cells. Recent evidence suggests that the formation of adult intestinal stem cells in mammals takes place during the thyroid hormone-d...

journal_title：Seminars in cell & developmental biology

authors： Fu L,Shi YB

更新日期：2017-03-01 00:00:00

abstract：:The design and analysis of experiments using gene expression microarrays is a topic of considerable current research, and work is beginning to appear on the analysis of proteomics and metabolomics data by mass spectrometry and NMR spectroscopy. The literature in this area is evolving rapidly, and commercial software f...

journal_title：Seminars in cell & developmental biology

authors： Rocke DM

更新日期：2004-12-01 00:00:00

abstract：:Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression is principally governed by one catalytic subunit (cyclin-dependent kinase) that pairs with cell cycle-specific regulatory subuni...

journal_title：Seminars in cell & developmental biology

authors： Sánchez I,Dynlacht BD

更新日期：2005-06-01 00:00:00