Abstract:
:Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Alculumbre S,Raieli S,Hoffmann C,Chelbi R,Danlos FX,Soumelis Vdoi
10.1016/j.semcdb.2018.02.014subject
Has Abstractpub_date
2019-02-01 00:00:00pages
24-35eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30385-3journal_volume
86pub_type
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