Abstract：
:The vertebrate brain is organized, from its embryonic origin and throughout adult life, around a dynamic and complex fluid, the cerebrospinal fluid (CSF). There is growing interest in the composition, dynamics and function of the CSF in brain development research. It has been demonstrated in higher vertebrates that CSF has key functions in delivering diffusible signals and nutrients to the developing brain, contributing to the proliferation, differentiation and survival of neural progenitor cells, and to the patterning of the brain. It has also been shown that the composition and the homeostasis of CSF are tightly regulated following the closure of the anterior neuropore, just before the initiation of primary neurogenesis in the neural tissue surrounding brain cavities, before the formation of functional choroid plexus. In this review we draw together existing literature about the composition and formation of embryonic cerebrospinal fluid in birds and mammals, from the closure of the anterior neuropore to the formation of functional fetal choroid plexus, including mechanisms regulating its composition and homeostasis. The significance of CSF regulation within embryonic brain is also discussed from an evolutionary perspective.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Bueno D,Parvas M,Nabiuni M,Miyan Jdoi
10.1016/j.semcdb.2019.09.006subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3-12eissn
1084-9521issn
1096-3634pii
S1084-9521(18)30241-6journal_volume
102pub_type
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