Abstract:
:The mechanistic (or mammalian) Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth and metabolism. By integrating mitogenic signals, mTORC1-dependent phosphorylation of substrates dictates the balance between anabolic, pro-growth and catabolic, recycling processes in the cell. The discovery that amino acids activate mTORC1 by promoting its translocation to the lysosome was a fundamental advance in the understanding of mTORC1 signalling. It has since become clear that the lysosome-cytoplasm shuttling of mTORC1 represents just one layer of spatial control of this signalling pathway. This review will focus on exploring the subcellular localisation of mTORC1 and its regulators to multiple sites within the cell. We will discuss how these spatially distinct regions such as endoplasmic reticulum, plasma membrane and the endosomal pathway co-operate to transduce nutrient availability to mTORC1, allowing for tight control of cell growth.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Carroll Bdoi
10.1016/j.semcdb.2020.02.007subject
Has Abstractpub_date
2020-11-01 00:00:00pages
103-111eissn
1084-9521issn
1096-3634pii
S1084-9521(19)30136-3journal_volume
107pub_type
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