Towards a genome-wide reconstruction of cis-regulatory networks in the human genome.

abstract：:Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [...

journal_title：Seminars in cell & developmental biology

authors： Crow ET,Li L

更新日期：2011-07-01 00:00:00

abstract：:There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hur...

journal_title：Seminars in cell & developmental biology

authors： Kind A,Colman A

更新日期：1999-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a prevalent inflammatory joint disease with enigmatic flares, which causes swelling, pain, and irreversible connective tissue damage. Recently, it has been demonstrated in murine models of RA that the popliteal lymph node (PLN) is a biomarker of arthritic flare, as it "expands" in size and...

journal_title：Seminars in cell & developmental biology

authors： Bouta EM,Li J,Ju Y,Brown EB,Ritchlin CT,Xing L,Schwarz EM

更新日期：2015-02-01 00:00:00

abstract：:Rhomboids are conserved intramembrane serine proteases with widespread functions. They were the earliest discovered members of the wider rhomboid-like superfamily of proteases and pseudoproteases. The secretase class of rhomboid proteases, distributed through the secretory pathway, are the most numerous in eukaryotes,...

journal_title：Seminars in cell & developmental biology

authors： Lastun VL,Grieve AG,Freeman M

更新日期：2016-12-01 00:00:00

abstract：:The notion of feedback is fundamental for understanding signal transduction networks. Feedback loops attenuate or amplify signals, change the network dynamics and modify the input-output relationships between the signal and the target. Negative feedback provides robustness to noise and adaptation to perturbations, but...

journal_title：Seminars in cell & developmental biology

authors： Nguyen LK,Kholodenko BN

更新日期：2016-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as an essential regulatory component in plants. Many of the known miRNAs are evolutionarily conserved across diverse plant species and function in the regulatory control of fundamentally important biological processes such as developmental timing, patterning, and response to environment...

journal_title：Seminars in cell & developmental biology

authors： Xie Z,Khanna K,Ruan S

更新日期：2010-10-01 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:The use of the adapted models to decipher patho-physiological mechanisms of human diseases is always a great challenge. This is of particular importance for early-onset myopathies, in which pathological mutations often impact not only on muscle structure and function but also on developmental processes. Mice are curre...

journal_title：Seminars in cell & developmental biology

authors： Jagla K,Kalman B,Boudou T,Hénon S,Batonnet-Pichon S

更新日期：2017-04-01 00:00:00

abstract：:The epithalamus of zebrafish presents the best-studied case of directional asymmetry in the vertebrate brain. Epithalamic asymmetries are coupled to visceral asymmetry and include left-sided migration of a single midline structure (the parapineal organ) and asymmetric differentiation of paired bilateral nuclei (habenu...

journal_title：Seminars in cell & developmental biology

authors： Concha ML,Signore IA,Colombo A

更新日期：2009-06-01 00:00:00

abstract：:Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a hig...

journal_title：Seminars in cell & developmental biology

authors： Burr R,Espenshade PJ

更新日期：2018-09-01 00:00:00

abstract：:Analysis of membrane transport in the yeast Saccharomyces cerevisiae continues to provide important insights into the molecular mechanisms that direct endocytic and lysosomal sorting pathways in eukaryotic cells. Recent findings include the identification of two novel endomembrane transport pathways, a Golgi-to-vacuol...

journal_title：Seminars in cell & developmental biology

authors： Burd CG,Babst M,Emr SD

更新日期：1998-10-01 00:00:00

abstract：:Wnt signaling is a hallmark of all embryonic development with multiple roles at multiple developmental time points. Wnt signaling is also important in the development of several organs, one of which is the inner ear, where it participates in otic specification, the formation of vestibular structures, and the developme...

journal_title：Seminars in cell & developmental biology

authors： Munnamalai V,Fekete DM

更新日期：2013-05-01 00:00:00

abstract：:Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over dis...

journal_title：Seminars in cell & developmental biology

authors： Niethammer P

更新日期：2018-08-01 00:00:00

abstract：:Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, th...

journal_title：Seminars in cell & developmental biology

authors： D'Uva G,Lauriola M

更新日期：2016-02-01 00:00:00

abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...

journal_title：Seminars in cell & developmental biology

authors： Campàs O

更新日期：2016-07-01 00:00:00

abstract：:Complement and dendritic cells (DCs) share many functional features that drive the outcome of immune-inflammatory processes. Both have a sentinel function, acting as danger sensors specialized for a rapid, comprehensive and selective action against potential threats without damaging the healthy host cells. But while c...

journal_title：Seminars in cell & developmental biology

authors： Luque A,Serrano I,Aran JM

更新日期：2019-01-01 00:00:00

abstract：:Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression is principally governed by one catalytic subunit (cyclin-dependent kinase) that pairs with cell cycle-specific regulatory subuni...

journal_title：Seminars in cell & developmental biology

authors： Sánchez I,Dynlacht BD

更新日期：2005-06-01 00:00:00

abstract：:Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation t...

journal_title：Seminars in cell & developmental biology

authors： Fritzsch B,Silos-Santiago I I,Bianchi LM,Fariñas I I

更新日期：1997-06-01 00:00:00

abstract：:Cichlid fishes constitute one of the most species-rich families of vertebrates. In addition to complex social behaviour and morphological versatility, they are characterised by extensive diversity in colouration, both within and between species. Here, we review the cellular and molecular mechanisms underlying colour v...

journal_title：Seminars in cell & developmental biology

authors： Maan ME,Sefc KM

更新日期：2013-06-01 00:00:00

abstract：:The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cel...

journal_title：Seminars in cell & developmental biology

authors： Meda F,Rampon C,Dupont E,Gauron C,Mourton A,Queguiner I,Thauvin M,Volovitch M,Joliot A,Vriz S

更新日期：2018-08-01 00:00:00

abstract：:The immune system consists of a heterogeneous ensemble of cell types that immunologists have tried to classify and order for decades. This classification has relied on varying criteria, resulting in major debates in the immunology community. Discovered in the late 1970s [1], dendritic cells (DCs) are no exception, and...

journal_title：Seminars in cell & developmental biology

authors： Perié L,Naik SH

更新日期：2015-05-01 00:00:00

abstract：:Planar cell polarity, the orientation of single-cell asymmetries within the plane of a multicellular tissue, is essential to generating the shape and dimensions of organs and organisms. Planar polarity systems align cell behavior with the body axes and orient the cellular processes that lead to tissue elongation. Usin...

journal_title：Seminars in cell & developmental biology

authors： Vichas A,Zallen JA

更新日期：2011-10-01 00:00:00

abstract：:Caspases are cysteine proteases that play important and well-defined roles in apoptosis and inflammation. Increasing evidence point to alternative functions of caspases where restricted and localized caspase activation within neurons allows for a variety of non-apoptotic and non-inflammatory processes required for bra...

journal_title：Seminars in cell & developmental biology

authors： Hollville E,Deshmukh M

更新日期：2018-10-01 00:00:00

abstract：:Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteris...

journal_title：Seminars in cell & developmental biology

authors： Gallagher IJ,Jacobi C,Tardif N,Rooyackers O,Fearon K

更新日期：2016-06-01 00:00:00

abstract：:The ancestors of modern Metazoa were constructed in large part by the foldings and distortions of two-dimensional sheets of epithelial cells. This changed approximately 600 million years ago with the evolution of mesenchymal cells. These cells arise as the result of epithelial cell delamination through a reprogramming...

journal_title：Seminars in cell & developmental biology

authors： Baum B,Settleman J,Quinlan MP

更新日期：2008-06-01 00:00:00

abstract：:The post-translational modification of proteins by covalent attachment of ubiquitin targets these proteins for degradation by the proteasome. An astounding number of proteins are involved in ubiquitination and deubiquitination of proteins. The pathways are combinatorial, and selectivity of proteolysis will depend stro...

journal_title：Seminars in cell & developmental biology

authors： Wilkinson KD

更新日期：2000-06-01 00:00:00

abstract：:Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...

journal_title：Seminars in cell & developmental biology

authors： Moosa MM,Ferreon JC,Ferreon ACM

更新日期：2020-03-01 00:00:00

abstract：:No abstractCopyright 1997 Academic Press Limited Copyright 1997Academic Press Limited ...

journal_title：Seminars in cell & developmental biology

authors： Bard JBI

更新日期：1997-10-01 00:00:00

abstract：:The pharyngeal arches form the face and neck of the developing embryo. The pharyngeal tissue is divided into distinct arches by the formation of clefts and pouches in between the arches. These clefts and pouches form at the juxtaposition between the ectoderm and endoderm and develop into a variety of essential structu...

journal_title：Seminars in cell & developmental biology

authors： Grevellec A,Tucker AS

更新日期：2010-05-01 00:00:00

abstract：:Carotenoids are an important source of metabolites with regulatory function, which include the plant hormones abscisic acid (ABA) and strigolactones (SLs), and several recently identified growth regulators and signaling molecules. These carotenoid-derivatives originate from oxidative breakdown of double bonds in the c...

journal_title：Seminars in cell & developmental biology

authors： Wang JY,Lin PY,Al-Babili S

更新日期：2020-07-27 00:00:00