Abstract：
:Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral border in invertebrates. Among the polarity complexes, two are present at the apical side of epithelial cells. These are the Par complex including aPKC, PAR3 and PAR6 and the Crumbs complex including, CRUMBS, PALS1 and PATJ/MUPP1. These two complexes interact directly and in addition to their already well described functions, they play a role in other cellular processes such as ciliogenesis and polarized cell migration. In this review, we will focus on these aspects that involve the apical Crumbs polarity complex and its relation with the cortical actin cytoskeleton which might provide a more comprehensive hypothesis to explain the many facets of Crumbs cell and tissue properties.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Bazellières E,Aksenova V,Barthélémy-Requin M,Massey-Harroche D,Le Bivic Adoi
10.1016/j.semcdb.2017.10.018subject
Has Abstractpub_date
2018-09-01 00:00:00pages
13-20eissn
1084-9521issn
1096-3634pii
S1084-9521(16)30333-0journal_volume
81pub_type
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