Abstract：
:Early life adversity remains a significant risk factor for the development of a host of negative behavioural and pathological outcomes in adulthood long after the stressor is over. Recent evidence indicates that these lasting effects of ELS may occur via alterations in the epigenetic landscape. Here, we review the main findings of the effects of early life adversity on DNA methylation, histone post-translational modification, and non-coding RNAs in the context of psychiatric disease in animal models and human cohorts. We specifically explore how early life adversity alters epigenetic patterns in both a global manner, and in specific candidate genes that play a role in relevant systems such as the hypothalamic-pituitary-adrenal axis, as well as neurotransmitter and neuroendocrine signalling. We also discuss how individual factors, such as genetics, sex, and age, as well as the type, and timing of early life adversity, can create differential susceptibility and significantly moderate outcomes. Although challenges remain in deciphering the complexity of how the early environment interacts with individual factors to determine epigenetic patterns, as well as how to translate these mechanistic findings into clinically relevant populations, the reviewed literature sheds light on the potential of the field to identify effective interventions for vulnerable individuals.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Burns SB,Szyszkowicz JK,Luheshi GN,Lutz PE,Turecki Gdoi
10.1016/j.semcdb.2017.09.033subject
Has Abstractpub_date
2018-05-01 00:00:00pages
115-132eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30370-1journal_volume
77pub_type
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