Lipid distribution and transport across cellular membranes.

Abstract:

:In eukaryotic cells, the membranes of different intracellular organelles have different lipid composition, and various biomembranes show an asymmetric distribution of lipid types across the membrane bilayer. Membrane lipid organization reflects a dynamic equilibrium of lipids moving across the bilayer in both directions. In this review, we summarize data supporting the role of specific membrane proteins in catalyzing transbilayer lipid movement, thereby controlling and regulating the distribution of lipids over the leaflets of biomembranes.

journal_name

Semin Cell Dev Biol

authors

Pomorski T,Hrafnsdóttir S,Devaux PF,van Meer G

doi

10.1006/scdb.2000.0231

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

139-48

issue

2

eissn

1084-9521

issn

1096-3634

pii

S1084-9521(00)90231-3

journal_volume

12

pub_type

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