Planar cell polarity and vertebrate organogenesis.

abstract：:Regulation of Notch signaling is critical to development and maintenance of most eukaryotic organisms. The Notch receptors and ligands are integral membrane proteins and direct cell-cell interactions are needed to activate signaling. Ligand-expressing cells activate Notch signaling through an unusual mechanism involvi...

journal_title：Seminars in cell & developmental biology

authors： Musse AA,Meloty-Kapella L,Weinmaster G

更新日期：2012-06-01 00:00:00

abstract：:Adenosine- and uridine-rich elements (AREs) located in 3'-untranslated regions are the best-known determinants of RNA instability. These elements have also been shown to control translation in certain mRNAs, including mRNAs for prominent pro-inflammatory and tumor growth-related proteins, and physiological anti-inflam...

journal_title：Seminars in cell & developmental biology

authors： Espel E

更新日期：2005-02-01 00:00:00

abstract：:The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under...

journal_title：Seminars in cell & developmental biology

authors： Biggins JS,Royer C,Watanabe T,Srinivas S

更新日期：2015-12-01 00:00:00

abstract：:With the arrival of atomic force microscopy (AFM) about thirty years ago, this new imaging tool opened up a new area for the exploration of biological samples, ranging from the tissue and cellular level down to the supramolecular scale. Commercial instruments of this new imaging technique began to appear in the five y...

journal_title：Seminars in cell & developmental biology

authors： Braet F,Taatjes DJ,Wisse E

更新日期：2018-01-01 00:00:00

abstract：:During the development of vertebrate nervous system, distinct classes of motor neurons and interneurons are generated at distinct dorsoventral positions in the ventral neural tube. The differentiation of these neuronal subtypes is directed by the secreted protein Sonic Hedgehog (Shh). Shh acts in a graded manner to es...

journal_title：Seminars in cell & developmental biology

authors： Briscoe J,Ericson J

更新日期：1999-06-01 00:00:00

abstract：:In 1962, epidermal growth factor (EGF) was discovered by Dr. Stanley Cohen while studying nerve growth factor (NGF). It was soon recognized that EGF is the prototypical member of a family of peptide growth factors that activate the EGF receptors, and that the EGF/EGF receptor signaling pathway plays important roles in...

journal_title：Seminars in cell & developmental biology

authors： Zeng F,Harris RC

更新日期：2014-04-01 00:00:00

abstract：:Lipid droplets (LDs) are versatile organelles with central roles in lipid and energy metabolism in all eukaryotes. They primarily buffer excess fatty acids by storing them as neutral lipids, mainly triglycerides and steryl esters. The neutral lipids form a core, surrounded by a unique phospholipid monolayer coated wit...

journal_title：Seminars in cell & developmental biology

authors： Renne MF,Klug YA,Carvalho P

更新日期：2020-12-01 00:00:00

abstract：:Some epithelial cells are polarized along an axis orthogonal to their apical-basal axes. Recent studies in Drosophila lead to the view that three classes of signaling molecules govern the planar cell polarity (PCP) pathway. The first class, or module, functions across whole tissues, providing directional information t...

journal_title：Seminars in cell & developmental biology

authors： Tree DR,Ma D,Axelrod JD

更新日期：2002-06-01 00:00:00

abstract：:Cell signaling is essential for cells to adequately respond to their environment. One of the most evolutionarily conserved signaling pathways is that of the epidermal growth factor receptor (EGFR). Transmembrane receptors with intracellular tyrosine kinase activity are activated by the binding of their corresponding l...

journal_title：Seminars in cell & developmental biology

authors： Barberán S,Cebrià F

更新日期：2019-03-01 00:00:00

abstract：:The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membra...

journal_title：Seminars in cell & developmental biology

authors： Granger E,McNee G,Allan V,Woodman P

更新日期：2014-07-01 00:00:00

abstract：:Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group...

journal_title：Seminars in cell & developmental biology

authors： Le Nours J,Shahine A,Gras S

更新日期：2018-12-01 00:00:00

abstract：:There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hur...

journal_title：Seminars in cell & developmental biology

authors： Kind A,Colman A

更新日期：1999-06-01 00:00:00

abstract：:Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose ne...

journal_title：Seminars in cell & developmental biology

authors： Sun YE,Martinowich K,Ge W

更新日期：2003-06-01 00:00:00

abstract：:Vitamin B12 (cobalamin) is necessary for development of the fetus and child. Pregnant women who are vegetarian or vegan, have Crohn's or celiac disease, or have undergone gastric bypass surgery are at increased risk of B12 deficiency. Low serum levels of B12 have been linked to negative impacts in cognitive, motor, an...

journal_title：Seminars in cell & developmental biology

authors： Pepper MR,Black MM

更新日期：2011-08-01 00:00:00

abstract：:Control of translation allows for the production of stoichiometric levels of each protein in the cell. Attaining such a level of fine-tuned regulation of protein production requires the coordinated temporal and spatial control of numerous cellular signalling cascades impinging on the various components of the translat...

journal_title：Seminars in cell & developmental biology

authors： Fonseca BD,Smith EM,Yelle N,Alain T,Bushell M,Pause A

更新日期：2014-12-01 00:00:00

abstract：:The proinflammatory cytokine tumor necrosis factor (TNF) orchestrates complex multicellular processes through a wide variety of changes that it induces in cell functions. At various stages of the study of TNF, attention has been drawn to one of three different modes of its action. The work that led to the discovery of...

journal_title：Seminars in cell & developmental biology

authors： Wallach D

更新日期：2016-02-01 00:00:00

abstract：:Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransfer...

journal_title：Seminars in cell & developmental biology

authors： Grant PA,Berger SL

更新日期：1999-04-01 00:00:00

abstract：:Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions...

journal_title：Seminars in cell & developmental biology

authors： Kim M,Bjorke B,Mastick GS

更新日期：2019-01-01 00:00:00

abstract：:Pollen tubes extend rapidly in an oscillatory manner by the extreme form of polarized growth, tip growth, and provide an exciting system for studying the spatiotemporal control of polarized cell growth. The Rho-family ROP GTPase is a key signaling molecule in this growth control and is periodically activated at the ap...

journal_title：Seminars in cell & developmental biology

authors： Qin Y,Yang Z

更新日期：2011-10-01 00:00:00

abstract：:The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive third degree burn...

journal_title：Seminars in cell & developmental biology

authors： Barrandon Y,Grasset N,Zaffalon A,Gorostidi F,Claudinot S,Droz-Georget SL,Nanba D,Rochat A

更新日期：2012-10-01 00:00:00

abstract：:The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and ben...

journal_title：Seminars in cell & developmental biology

authors： Hou L,Srivastava Y,Jauch R

更新日期：2017-03-01 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of ot...

journal_title：Seminars in cell & developmental biology

authors： Lingaraju A,Long TM,Wang Y,Austin JR 2nd,Turner JR

更新日期：2015-06-01 00:00:00

abstract：:The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies ...

journal_title：Seminars in cell & developmental biology

authors： Draghi J

更新日期：2019-04-01 00:00:00

abstract：:Multivesicular bodies (MVBs) are ubiquitous endocytic organelles containing numerous 50-80 nm vesicles. MVBs are very dynamic in shape and function. In antigen presenting cells (APCs), MVBs play a central role in the loading of major histocompatibility complex class II (MHC II) with antigenic peptides. How MHC II is t...

journal_title：Seminars in cell & developmental biology

authors： Murk JL,Stoorvogel W,Kleijmeer MJ,Geuze HJ

更新日期：2002-08-01 00:00:00

abstract：:The family Cichlidae contains approximately 2000 species that live in diverse freshwater habitats including murky lakes, turbid rivers, and clear lakes from both the Old and New Worlds. Their visual systems are similarly diverse and have evolved specific sensitivities that differ along several axes of variation. Varia...

journal_title：Seminars in cell & developmental biology

authors： Carleton KL,Yourick MR

更新日期：2020-10-01 00:00:00

abstract：:The vast amount of recent progress made on the sequence of the human genome has allowed an unprecedented examination of cis-regulatory networks. These networks consist of functional elements such as promoters, enhancers, silencers, and insulators, and their coordinated activity is responsible for regulation of gene ex...

journal_title：Seminars in cell & developmental biology

authors： Cecchini KR,Raja Banerjee A,Kim TH

更新日期：2009-09-01 00:00:00

abstract：:Vitamin A and its derivatives, the retinoids, have been implicated as important signaling molecules in vertebrate development, primarily due to numerous gain-of-function experiments involving treatment of embryos with exogenous retinoic acid. Collectively, the results from these experiments suggested that retinoids we...

journal_title：Seminars in cell & developmental biology

authors： Blumberg B

更新日期：1997-08-01 00:00:00

abstract：:Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the c...

journal_title：Seminars in cell & developmental biology

authors： Chakraborty S,Davis MJ,Muthuchamy M

更新日期：2015-02-01 00:00:00

abstract：:Pigment cells serve a variety of important uses across the animal kingdom, and in many species can change and regenerate throughout the lifetime of the organism. The functions of these cells, as well as their origins in both embryonic development and adult regeneration, are not fully understood. Here, we review advanc...

journal_title：Seminars in cell & developmental biology

authors： Lindsay-Mosher N,Pearson BJ

更新日期：2019-03-01 00:00:00