Abstract：
:APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized. Under appropriate conditions APOBEC1 also deaminates deoxycytidine in single-stranded DNA (ssDNA). The other ten members of the APOBEC family have not been fully characterized however several have deoxycytidine deaminase activity on ssDNAs. Despite the nucleic acid substrate preferences of different APOBEC proteins, a common feature appears to be their intrinsic ability to bind to RNA as well as to ssDNA. RNA binding to APOBEC proteins together with protein-protein interactions, post-translation modifications and subcellular localization serve as biological modulators controlling the DNA mutagenic activity of these potentially genotoxic proteins.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Smith HC,Bennett RP,Kizilyer A,McDougall WM,Prohaska KMdoi
10.1016/j.semcdb.2011.10.004subject
Has Abstractpub_date
2012-05-01 00:00:00pages
258-68issue
3eissn
1084-9521issn
1096-3634pii
S1084-9521(11)00183-2journal_volume
23pub_type
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