Functions and regulation of the APOBEC family of proteins.

abstract：:The design and analysis of experiments using gene expression microarrays is a topic of considerable current research, and work is beginning to appear on the analysis of proteomics and metabolomics data by mass spectrometry and NMR spectroscopy. The literature in this area is evolving rapidly, and commercial software f...

journal_title：Seminars in cell & developmental biology

authors： Rocke DM

更新日期：2004-12-01 00:00:00

abstract：:The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under...

journal_title：Seminars in cell & developmental biology

authors： Biggins JS,Royer C,Watanabe T,Srinivas S

更新日期：2015-12-01 00:00:00

abstract：:Since the first implication of the core planar cell polarity (PCP) pathway in stereocilia orientation of sensory hair cells in the mammalian cochlea, much has been written about this subject, in terms of understanding how this pathway can shape the mammalian hair cells and using the inner ear as a model system to unde...

journal_title：Seminars in cell & developmental biology

authors： Ezan J,Montcouquiol M

更新日期：2013-05-01 00:00:00

abstract：:Multiple dimensions of genome organization play critical roles in the regulation of non-coding regions in gene expression in cell/organ development and pathogenesis. Precise measurements of multi-dimensional genome structure ensure data quality and fully depend upon the study design. We here overview the number of met...

journal_title：Seminars in cell & developmental biology

authors： Qian M,Cheng Y,Wang X

更新日期：2019-06-01 00:00:00

abstract：:Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral bo...

journal_title：Seminars in cell & developmental biology

authors： Bazellières E,Aksenova V,Barthélémy-Requin M,Massey-Harroche D,Le Bivic A

更新日期：2018-09-01 00:00:00

abstract：:From the mid-19th century until the 1980's, frogs and toads provided important research models for many fundamental questions in visual neuroscience. In the present century, they have been largely neglected. Yet they are animals with highly developed vision, a complex retina built on the basic vertebrate plan, an acce...

journal_title：Seminars in cell & developmental biology

authors： Donner K,Yovanovich CAM

更新日期：2020-10-01 00:00:00

abstract：:For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-sp...

journal_title：Seminars in cell & developmental biology

authors： Kim DK,Lee J,Simpson RJ,Lötvall J,Gho YS

更新日期：2015-04-01 00:00:00

abstract：:The capacity of cells and animals to sense and adapt to fluctuations in the availability of energetic substrates is commonly described as metabolic flexibility. This flexibility allows for example the transition from fed to fasting states and to meet the energy demands of exercise in both states. Flexibility is disrup...

journal_title：Seminars in cell & developmental biology

authors： Bosch M,Parton RG,Pol A

更新日期：2020-12-01 00:00:00

abstract：:In all organisms tRNAs play the essential role of connecting the genetic information found in DNA with the protein synthesis machinery ensuring fidelity during translation. Following transcription tRNAs undergo a number of processing events including numerous post-transcriptional modifications that render a tRNA molec...

journal_title：Seminars in cell & developmental biology

authors： Paris Z,Fleming IM,Alfonzo JD

更新日期：2012-05-01 00:00:00

abstract：:Additional copies of genes resulting from two whole genome duplications at the base of the vertebrates have been suggested as enabling the evolution of vertebrate-specific structures such as neural crest, a midbrain/hindbrain organizer and neurogenic placodes. These structures, however, did not evolve entirely de novo...

journal_title：Seminars in cell & developmental biology

authors： Holland LZ

更新日期：2013-02-01 00:00:00

abstract：:α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...

journal_title：Seminars in cell & developmental biology

authors： Yan X,Uronen RL,Huttunen HJ

更新日期：2020-03-01 00:00:00

abstract：:Analysis of membrane transport in the yeast Saccharomyces cerevisiae continues to provide important insights into the molecular mechanisms that direct endocytic and lysosomal sorting pathways in eukaryotic cells. Recent findings include the identification of two novel endomembrane transport pathways, a Golgi-to-vacuol...

journal_title：Seminars in cell & developmental biology

authors： Burd CG,Babst M,Emr SD

更新日期：1998-10-01 00:00:00

abstract：:Recent appraisals of mesenteric anatomy clarify its structure and show a continuous and helical-shaped organ. This new model signifies a departure from the conventional model which described multiple, separate "mesenteries". Renaissance anatomists depicted the mesentery as a continuous structure. Events that led to re...

journal_title：Seminars in cell & developmental biology

authors： Byrnes KG,Walsh D,Lewton-Brain P,McDermott K,Coffey JC

更新日期：2019-08-01 00:00:00

abstract：:gamma-Secretase is a membrane-embedded proteolytic complex composed of presenilin and three other subunits. The gamma-secretase complex generates the amyloid beta-peptide of Alzheimer's disease but also plays important roles in normal physiology, especially in signaling from the Notch receptor. How this hydrolytic enz...

journal_title：Seminars in cell & developmental biology

authors： Wolfe MS

更新日期：2009-04-01 00:00:00

abstract：:Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...

journal_title：Seminars in cell & developmental biology

authors： Nie P,Vartak A,Li YM

更新日期：2020-09-01 00:00:00

abstract：:The retrograde trafficking from endosomes to the trans-Golgi network (TGN) is one of the major endocytic pathways to divert proteins and lipids away from lysosomal degradation. Retrograde transported cargos enter the TGN via two itineraries from either the early endosome/recycling endosome or the late endosome and inv...

journal_title：Seminars in cell & developmental biology

authors： Lu L,Hong W

更新日期：2014-07-01 00:00:00

abstract：:Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteris...

journal_title：Seminars in cell & developmental biology

authors： Gallagher IJ,Jacobi C,Tardif N,Rooyackers O,Fearon K

更新日期：2016-06-01 00:00:00

abstract：:The functional unit of the mammalian metanephric kidney is the nephron: a complex tubular structure dedicated to blood filtration and maintenance of several important physiological functions. Nephrons are assembled from a nephron-restricted pool of mesenchymal progenitors over an extensive developmental period that is...

journal_title：Seminars in cell & developmental biology

authors： O'Brien LL,McMahon AP

更新日期：2014-12-01 00:00:00

abstract：:A substantial fraction of the human proteome encodes disordered proteins. Protein disorder is associated with a variety of cellular functions and misfunction, and is therefore of clear import to biological systems. However, disorder lends itself to conformational flexibility and heterogeneity, rendering proteins which...

journal_title：Seminars in cell & developmental biology

authors： Lee T,Moran-Gutierrez CR,Deniz AA

更新日期：2015-01-01 00:00:00

abstract：:The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing patches of sensory epithelia, each with a specialised function. The ear contains many different...

journal_title：Seminars in cell & developmental biology

authors： Alsina B,Whitfield TT

更新日期：2017-05-01 00:00:00

abstract：:Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently b...

journal_title：Seminars in cell & developmental biology

authors： Tanizawa H,Noma K

更新日期：2012-04-01 00:00:00

abstract：:The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned ...

journal_title：Seminars in cell & developmental biology

authors： Ebnet K,Kummer D,Steinbacher T,Singh A,Nakayama M,Matis M

更新日期：2018-09-01 00:00:00

abstract：:The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germl...

journal_title：Seminars in cell & developmental biology

authors： Young JC,Wakitani S,Loveland KL

更新日期：2015-09-01 00:00:00

abstract：:Stem cells have become one of the "buzz" topics in the last decade or so. One of the best systems to study adult stem cells in vivo is in the model organism, Drosophila melanogaster. One hundred years of genetic analysis, a sequenced and highly annotated genome and genomics makes this a difficult organism to avoid. Th...

journal_title：Seminars in cell & developmental biology

authors： Gregory L,Came PJ,Brown S

更新日期：2008-08-01 00:00:00

abstract：:The mammalian hearts have the least regenerative capabilities among tissues and organs. As such, heart regeneration has been and continues to be the ultimate goal in the treatment against acquired and congenital heart diseases. Uncovering such a long-awaited therapy is still extremely challenging in the current settin...

journal_title：Seminars in cell & developmental biology

authors： Witman N,Zhou C,Grote Beverborg N,Sahara M,Chien KR

更新日期：2020-04-01 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:The formation of ovules is a key step in the plant life cycle which alternates between a diploid and haploid generation, the sporophyte and the gametophyte. The transitions between the two generations in the female occur in the ovule, the site of meiosis, female gametogenesis and double fertilization. The intimate ass...

journal_title：Seminars in cell & developmental biology

authors： Grossniklaus U,Schneitz K

更新日期：1998-04-01 00:00:00

abstract：:During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilob...

journal_title：Seminars in cell & developmental biology

authors： Heisenberg CP,Tada M

更新日期：2002-12-01 00:00:00

abstract：:Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are approximately 14 families of kinesins within the kinesin superfamily. Family classification is derived primarily from alignments of the sequences of the core motor domain. For this reason, the enzymatic behavior and motility of each ...

journal_title：Seminars in cell & developmental biology

authors： Wordeman L

更新日期：2010-05-01 00:00:00

abstract：:Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pa...

journal_title：Seminars in cell & developmental biology

authors： Schatz M,Tong PBV,Beaumelle B

更新日期：2018-11-01 00:00:00