Abstract：
:The vertebrate ocular lens is a fascinating and unique transparent tissue that grows continuously throughout life. During the process of differentiation into fiber cells, lens epithelial cells undergo dramatic morphological changes, membrane remodeling, polarization, transcriptional activation and elimination of cellular organelles including nuclei, concomitant with migration towards the lens interior. Most of these events are presumed to be influenced in large part, by dynamic reorganization of the cellular actin cytoskeleton and by intercellular and cell: extracellular matrix interactions. In light of recent and unprecedented advancement in our understanding of the mechanistic bases underlying regulation of actin cytoskeletal dynamics and the role of the actin cytoskeleton in cell function, this review attempts to summarize current knowledge regarding the role of the cellular actin cytoskeleton, in lens fiber cell elongation and differentiation, and regulation of actin cytoskeletal organization in the lens.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Rao PV,Maddala Rdoi
10.1016/j.semcdb.2006.10.011subject
Has Abstractpub_date
2006-12-01 00:00:00pages
698-711issue
6eissn
1084-9521issn
1096-3634pii
S1084-9521(06)00108-Xjournal_volume
17pub_type
杂志文章,评审abstract：:Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a convergent body of biochemical and molecular genetic studies have confirmed their structural and functional relationship as an integrative hub through which regulatory information conveyed by signal activated transcription fact...
journal_title：Seminars in cell & developmental biology
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abstract：:We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative an...
journal_title：Seminars in cell & developmental biology
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abstract：:We have successfully produced "Mito-mice" harbouring a pathogenic mtDNA mutation. We generated the mice by introducing mitochondria with a 4696 base-pair mtDNA deletion (Delta mtDNA4696) into mouse embryos. This deletion encompasses nucleotides 7759-12 454 and includes six tRNA genes and seven structural genes. In Mit...
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pub_type： 杂志文章
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.semcdb.2017.08.028
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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journal_title：Seminars in cell & developmental biology
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更新日期：2017-09-01 00:00:00
abstract：:The integration of living cells together with silicon field-effect devices challenges a new generation of biosensors and bioelectronic devices. Cells are representing highly organised complex systems, optimised by millions of years of evolution and offering a broad spectrum of bioanalytical receptor "tools" such as en...
journal_title：Seminars in cell & developmental biology
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更新日期：2009-02-01 00:00:00
abstract：:The simple mechanistic and functional division of the kinesin family into either active translocators or non-motile microtubule depolymerases was initially appropriate but is now proving increasingly unhelpful, given evidence that several translocase kinesins can affect microtubule dynamics, whilst non-translocase kin...
journal_title：Seminars in cell & developmental biology
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
