Abstract:
:Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral circulation, playing a crucial role in the maintenance of the strict environment required for normal brain function.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Serlin Y,Shelef I,Knyazer B,Friedman Adoi
10.1016/j.semcdb.2015.01.002subject
Has Abstractpub_date
2015-02-01 00:00:00pages
2-6eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00004-Xjournal_volume
38pub_type
杂志文章,评审abstract::α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...
journal_title:Seminars in cell & developmental biology
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abstract::Paramutation was initially described in maize and was defined as an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification of the other allele without modifying the DNA sequence [1,2]. Thus it implies that the paramutated allele conserves its new properties on ...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...
journal_title:Seminars in cell & developmental biology
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abstract::Anuran amphibians can regenerate the retina through differentiation of stem cells in the ciliary marginal zone and through transdifferentiation of the retinal pigmented epithelium. By contrast, the regeneration of the lens has been demonstrated only in larvae of species belonging to the Xenopus genus, where the lens r...
journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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pub_type: 杂志文章,评审
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abstract::The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...
journal_title:Seminars in cell & developmental biology
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abstract::The urinary collecting system is derived from an epithelial protrusion arising from the Wolffian duct called the ureteric bud (UB) by the signal from its inductive tissue, metanephric mesenchyme (MM). Targeted gene mutation studies have shown that several transcription factors and MM-secreted glial cell line-derived n...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cell & developmental biology
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abstract::The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...
journal_title:Seminars in cell & developmental biology
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abstract::Traumatic brain injury (TBI) is a neurological condition which affects a large number of individuals worldwide, across all ages. It can lead to major physical, cognitive and psychological impairment, and represents a considerable health cost burden. TBI is a heterogeneous condition and there has been intense effort ov...
journal_title:Seminars in cell & developmental biology
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