Abstract:
:Centrioles and basal bodies are MT based structures that present a highly conserved ninefold symmetry. Centrioles can be found at the core of the centrosome where they participate in PCM recruitment and organization, contributing to cytoplasmic MT nucleation. Basal bodies are normally located closely to the plasma membrane where they are responsible for axoneme assembly to form structures such as cilia or flagella. While it is well accepted that these organelles have important roles in cell and tissue organization, their contribution to certain phases of animal development is still not entirely established. Here we review the role of centrosomes and cilia in Drosophila melanogaster and briefly discuss the implications of these findings to other model organisms.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Gogendeau D,Basto Rdoi
10.1016/j.semcdb.2009.07.001subject
Has Abstractpub_date
2010-04-01 00:00:00pages
163-73issue
2eissn
1084-9521issn
1096-3634pii
S1084-9521(09)00148-7journal_volume
21pub_type
杂志文章,评审abstract::It is increasingly recognized that the non-neoplastic stromal compartment in most solid cancers plays an active role in tumor proliferation, invasion and metastasis. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types in the tumor stroma, and these cells are pro-tumorigenic. Evidence that CAFs...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2009.10.001
更新日期:2010-02-01 00:00:00
abstract::Dictyostelium cells are genetically haploid and therefore easily analyzed for mutant phenotypes. In the past, many tools and molecular markers have been developed for a quantitative and qualitative analysis of the endocytic pathway in these amoebae. This review outlines parallels and discrepancies between mutants in D...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2010.11.001
更新日期:2011-02-01 00:00:00
abstract::The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive third degree burn...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.09.011
更新日期:2012-10-01 00:00:00
abstract::Flies escape danger by jumping into the air and flying away. The giant fibre system (GFS) is the neural circuit that mediates this simple behavioural response to visual stimuli. The sensory signal is received by the giant fibre and relayed to the leg and wing muscle motorneurons. Many of the neurons in the Drosophila ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.11.011
更新日期:2006-02-01 00:00:00
abstract::In recent years, novel functions for a number of nuclear factors have been uncovered in the cytoplasm, mainly at the level of translation. These factors behave as multifunctional regulators of gene expression and many play key roles in cell differentiation and development. One of the best characterized examples is tha...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1006/scdb.1997.0181
更新日期:1997-12-01 00:00:00
abstract::The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.09.010
更新日期:2014-12-01 00:00:00
abstract::Both cell cycle progression and the ubiquitin-proteasome system (UPS) that drives it are precisely regulated. Enzymatically, many ubiquitylation and degradation reactions have been characterized in in vitro systems, providing insights into the fundamental mechanisms of the UPS. Biologically, a range of degradation eve...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.01.015
更新日期:2012-07-01 00:00:00
abstract::No abstractCopyright 1997 Academic Press Limited Copyright 1997Academic Press Limited ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1006/scdb.1997.0170
更新日期:1997-10-01 00:00:00
abstract::When studying the living endosome one must first recognise that we are not studying a single discrete organelle but rather a highly dynamic interconnected network of membrane-bound compartments. Endocytosed molecules are sorted and transported through various polymorphic intracellular organelles that mature and intera...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.03.027
更新日期:2014-07-01 00:00:00
abstract::In order for a successful pregnancy to occur, the embryo must attach to the luminal epithelial cells and invade into the stroma. Then, the surrounding stromal cells need to undergo decidualization in order to establish the vasculature necessary for survival of the embryo. These events in early pregnancy are tightly re...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2007.12.001
更新日期:2008-04-01 00:00:00
abstract::Gene duplication events produce both perfect and imperfect copies of genes. Perfect copies are said to be functionally redundant when knockout of one gene produces no 'scoreable', phenotypic effects. Preserving identical, duplicate copies of genes is problematic as all copies are prone to accumulate neutral mutations ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0337
更新日期:1999-10-01 00:00:00
abstract::Multivesicular bodies (MVBs) are ubiquitous endocytic organelles containing numerous 50-80 nm vesicles. MVBs are very dynamic in shape and function. In antigen presenting cells (APCs), MVBs play a central role in the loading of major histocompatibility complex class II (MHC II) with antigenic peptides. How MHC II is t...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102000605
更新日期:2002-08-01 00:00:00
abstract::The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germl...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.10.029
更新日期:2015-09-01 00:00:00
abstract::During development, diffusible ligands, known as morphogens, are thought to move across fields of cells, regulating gene expression in a concentration dependent manner. The case for morphogens has been convincingly made for the Decapentapleigic (Dpp), Wingless (Wg) and Hedgehog (Hh) proteins in the Drosophila wing. In...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084-9521(02)00014-9
更新日期:2002-04-01 00:00:00
abstract::The formation of ovules is a key step in the plant life cycle which alternates between a diploid and haploid generation, the sporophyte and the gametophyte. The transitions between the two generations in the female occur in the ovule, the site of meiosis, female gametogenesis and double fertilization. The intimate ass...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1997.0214
更新日期:1998-04-01 00:00:00
abstract::Neural stem cells (NSCs) are subscribed extraordinary potential in repair of the damaged nervous system. However, the molecular identity of NSCs has not been established. Most NSC cultures contain large numbers of multipotent, bipotent, and lineage restricted neural progenitors, the majority of which appear to lose ne...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084-9521(03)00007-7
更新日期:2003-06-01 00:00:00
abstract::The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of ot...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.04.008
更新日期:2015-06-01 00:00:00
abstract::Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trispho...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1997.0220
更新日期:1998-04-01 00:00:00
abstract::Mammalian core binding factor beta (CBFbeta) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBFbeta is essential for development and sust...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.2000.0189
更新日期:2000-10-01 00:00:00
abstract::Intrinsically disordered proteins as computationally predicted account for ∼1/3 of eukaryotic proteomes, are involved in a plethora of biological functions, and have been linked to several human diseases as a result of their dysfunctions. Here, we present a picture wherein an energetic continuum describes protein stru...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.05.007
更新日期:2020-03-01 00:00:00
abstract::Large-scale identification of elements associated with gene expression revealed that many of them are located extremely far from gene transcriptional start sites. We review here the growing evidence that show that distal cis-acting elements provide key instructions to genes, as genetic variation affecting them is grow...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.06.017
更新日期:2016-09-01 00:00:00
abstract::Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransfer...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0298
更新日期:1999-04-01 00:00:00
abstract::Mesoderm and endoderm formation in Xenopus involves the coordinated efforts of maternally and zygotically expressed transcription factors together with growth factor signalling, including members of the TGFbeta and wnt families. In this review we discuss our current state of knowledge of these pathways, and describe i...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.11.008
更新日期:2006-02-01 00:00:00
abstract::Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 198...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.09.005
更新日期:2012-04-01 00:00:00
abstract::Vitamin A and its derivatives, the retinoids, have been implicated as important signaling molecules in vertebrate development, primarily due to numerous gain-of-function experiments involving treatment of embryos with exogenous retinoic acid. Collectively, the results from these experiments suggested that retinoids we...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1006/scdb.1997.0165
更新日期:1997-08-01 00:00:00
abstract::One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through d...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.11.008
更新日期:2018-10-01 00:00:00
abstract::Phytochromes in harmony with blue light photoreceptors play a major role in controlling plant growth and development from germination to seed maturation. Light absorption by phytochromes triggers a signaling cascade, phototransduction, which culminates in regulated gene expression. A major regulatory step at the cellu...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.2000.0202
更新日期:2000-12-01 00:00:00
abstract::Control of translation allows for the production of stoichiometric levels of each protein in the cell. Attaining such a level of fine-tuned regulation of protein production requires the coordinated temporal and spatial control of numerous cellular signalling cascades impinging on the various components of the translat...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.09.014
更新日期:2014-12-01 00:00:00
abstract::Most mammals cannot easily overcome degenerative disease or traumatic injuries. In contrast, an innate ability to regenerate is observed across animal phyla. Freshwater planarians are amongst the organisms that are capable of stem cell-mediated whole-body regeneration and have served as an exemplary model to study how...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.04.009
更新日期:2019-03-01 00:00:00
abstract::Genomic instability resultant from defective DNA repair mechanisms is a fundamental hallmark of cancer. The poly(ADP-ribose) polymerase (PARP) proteins 1, 2 and 3 catalyze the polymerization of poly(ADP-ribose) and covalent attachment to proteins in a phylogenetically ancient form of protein modification. PARPs play a...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.01.007
更新日期:2017-03-01 00:00:00