Abstract:
:Eph receptor tyrosine kinases mediate cell-cell communication by interacting with ephrin ligands residing on adjacent cell surfaces. In doing so, these juxtamembrane signaling complexes provide important contextual information about the cellular microenvironment that helps orchestrate tissue morphogenesis and maintain homeostasis. Eph/ephrin signaling has been implicated in various aspects of mammalian skin physiology, with several members of this large family of receptor tyrosine kinases and their ligands present in the epidermis, hair follicles, sebaceous glands, and underlying dermis. This review focuses on the emerging role of Eph receptors and ephrins in epidermal keratinocytes where they can modulate proliferation, migration, differentiation, and death. The activation of Eph receptors by ephrins at sites of cell-cell contact also appears to play a key role in the maturation of intercellular junctional complexes as keratinocytes move out of the basal layer and differentiate in the suprabasal layers of this stratified, squamous epithelium. Furthermore, alterations in the epidermal Eph/ephrin axis have been associated with cutaneous malignancy, wound healing defects and inflammatory skin conditions. These collective observations suggest that the Eph/ephrin cell-cell communication pathway may be amenable to therapeutic intervention for the purpose of restoring epidermal tissue homeostasis and integrity in dermatological disorders.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Lin S,Wang B,Getsios Sdoi
10.1016/j.semcdb.2011.10.017subject
Has Abstractpub_date
2012-02-01 00:00:00pages
92-101issue
1eissn
1084-9521issn
1096-3634pii
S1084-9521(11)00205-9journal_volume
23pub_type
杂志文章,评审abstract::In the crowded intranuclear environment, entropic depletion forces between macromolecules are expected to be strong. A review of simulations of linear polymers leads to several predictions about probable conformations of a polynucleosome chain in these conditions. These include a globular conformation, variable compac...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2007.08.006
更新日期:2007-10-01 00:00:00
abstract::Cleavage furrow in animal cell cytokinesis is formed by cortical constriction driven by contraction of an actomyosin network activated by Rho GTPase. Although the role of the mitotic apparatus in furrow induction has been well established, there remain discussions about the detailed molecular mechanisms of the cleavag...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.03.006
更新日期:2016-05-01 00:00:00
abstract::Anuran amphibians can regenerate the retina through differentiation of stem cells in the ciliary marginal zone and through transdifferentiation of the retinal pigmented epithelium. By contrast, the regeneration of the lens has been demonstrated only in larvae of species belonging to the Xenopus genus, where the lens r...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2008.11.015
更新日期:2009-07-01 00:00:00
abstract::Polycomb group (PcG) proteins play essential roles in animal and plant life cycles by controlling the expression of important developmental regulators. These structurally heterogeneous proteins form multimeric protein complexes that control higher order chromatin structure and, thereby, the expression state of their t...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084-9521(02)00139-8
更新日期:2003-02-01 00:00:00
abstract::Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.11.016
更新日期:2019-01-01 00:00:00
abstract::Newly synthesized polypeptide chains must fold and assemble into unique three-dimensional structures in order to become functionally active. In many cases productive folding depends on assistance from molecular chaperones, which act in preventing off-pathway reactions during folding that lead to aggregation. The inher...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1006/scdb.1999.0347
更新日期:2000-02-01 00:00:00
abstract::Fibrillin microfibrils are extensible polymers that endow connective tissues with long-range elasticity and have widespread distributions in both elastic and non-elastic tissues. They act as a template for elastin deposition during elastic fibre formation and are essential for maintaining the integrity of tissues such...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.07.016
更新日期:2019-05-01 00:00:00
abstract::Given the large socio-economic burden of cancer, there is an urgent need for in vivo animal cancer models that can provide a rationale for personalised therapeutic regimens that are translatable to the clinic. Recent developments in establishing mouse models that closely resemble human lung cancers involve the applica...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.04.002
更新日期:2014-03-01 00:00:00
abstract::Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation t...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章
doi:10.1006/scdb.1997.0144
更新日期:1997-06-01 00:00:00
abstract::Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently b...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.11.003
更新日期:2012-04-01 00:00:00
abstract::The immune system consists of a heterogeneous ensemble of cell types that immunologists have tried to classify and order for decades. This classification has relied on varying criteria, resulting in major debates in the immunology community. Discovered in the late 1970s [1], dendritic cells (DCs) are no exception, and...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.02.004
更新日期:2015-05-01 00:00:00
abstract::IgE-mediated food allergy is a developing global health problem with prevalence rising at alarmingly fast rates. In this review, we discuss the interplay between genetics, epigenetics, and environmental exposures in the pathogenesis of food allergies. We aim to highlight the most recent evidence that suggests how epig...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.07.002
更新日期:2015-07-01 00:00:00
abstract::Acquisition of the pluripotent state coincides with epigenetic reprogramming of the X-chromosome. Female embryonic stem cells are characterized by the presence of two active X-chromosomes, cell differentiation by inactivation of one of the two Xs, and induced pluripotent stem cells by reactivation of the inactivated X...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2011.02.025
更新日期:2011-06-01 00:00:00
abstract::The functional unit of the mammalian metanephric kidney is the nephron: a complex tubular structure dedicated to blood filtration and maintenance of several important physiological functions. Nephrons are assembled from a nephron-restricted pool of mesenchymal progenitors over an extensive developmental period that is...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2014.08.014
更新日期:2014-12-01 00:00:00
abstract::The developmental processes that give rise to the animal body plan are exceedingly complex. Model systems such as Drosophila melanogaster have yielded profound insight into roles of conserved genes and genetic pathways in development. Drosophila development begins with the formation of sperm and eggs, and proceeds thr...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2009.02.006
更新日期:2009-07-01 00:00:00
abstract::The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive third degree burn...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2012.09.011
更新日期:2012-10-01 00:00:00
abstract::The Endosomal Sorting Complex Required for Transport (ESCRT) proteins form an evolutionarily conserved membrane remodelling machinery. Identified originally for their role in cargo sorting and remodelling of endosomal membranes during yeast vacuolar sorting, an extensive body of work now implicates a sub-complex of th...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.08.035
更新日期:2018-02-01 00:00:00
abstract::The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and ben...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.08.005
更新日期:2017-03-01 00:00:00
abstract::It is increasingly recognized that the non-neoplastic stromal compartment in most solid cancers plays an active role in tumor proliferation, invasion and metastasis. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types in the tumor stroma, and these cells are pro-tumorigenic. Evidence that CAFs...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2009.10.001
更新日期:2010-02-01 00:00:00
abstract::α-synuclein and Tau are proteins prone to pathological misfolding and aggregation that are normally found in the presynaptic and axonal compartments of neurons. Misfolding initiates a homo-oligomerization and aggregation cascade culminating in cerebral accumulation of aggregated α-synuclein and Tau in insoluble protei...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2018.05.005
更新日期:2020-03-01 00:00:00
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journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::The Notch signaling pathway is an evolutionarily conserved pathway that is critical for tissue morphogenesis during development, but is also involved in tissue maintenance and repair in the adult. In skeletal muscle, regulation of Notch signaling is involved in somitogenesis, muscle development, and the proliferation ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.07.002
更新日期:2005-08-01 00:00:00
abstract::Cichlid fishes constitute one of the most species-rich families of vertebrates. In addition to complex social behaviour and morphological versatility, they are characterised by extensive diversity in colouration, both within and between species. Here, we review the cellular and molecular mechanisms underlying colour v...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2013.05.003
更新日期:2013-06-01 00:00:00
abstract::A wide range of cellular activities including protein folding and cell secretion, such as neurotransmission or insulin release, are all governed by intracellular pH homeostasis, underscoring the importance of pH on critical life processes. Nano- scale pH measurements of cells and biomolecules therefore hold great prom...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2017.08.003
更新日期:2018-01-01 00:00:00
abstract::Cholesterol is highly enriched in the brain compared to other tissues. Essentially all cholesterol in the brain is synthesized endogenously since plasma lipoproteins are unable to cross the blood-brain barrier. Cholesterol is transported within the central nervous system in the form of apolipoprotein E-containing lipo...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.01.005
更新日期:2005-04-01 00:00:00
abstract::Hepatic oval cell activation, proliferation, and differentiation has been observed under certain physiological conditions, mainly when the proliferation of existing hepatocytes has been inhibited followed by severe hepatic injury. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential ...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/s1084952102001271
更新日期:2002-12-01 00:00:00
abstract::Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2020.12.004
更新日期:2021-01-04 00:00:00
abstract::A system of endoplasmic reticulum (ER) chaperones has evolved to optimize the output of properly folded secretory and membrane proteins. An important player in this network is Glucose Regulated Protein 94 (GRP94). Over the last decade, new structural and functional data have begun to delineate the unique characteristi...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2010.03.004
更新日期:2010-07-01 00:00:00
abstract::Mesoderm and endoderm formation in Xenopus involves the coordinated efforts of maternally and zygotically expressed transcription factors together with growth factor signalling, including members of the TGFbeta and wnt families. In this review we discuss our current state of knowledge of these pathways, and describe i...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2005.11.008
更新日期:2006-02-01 00:00:00
abstract::The TGF-β ligand superfamily contains at least 40 members, many of which are produced and act within the mammalian testis to facilitate formation of sperm. Their progressive expression at key stages and in specific cell types determines the fertility of adult males, influencing testis development and controlling germl...
journal_title:Seminars in cell & developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcdb.2015.10.029
更新日期:2015-09-01 00:00:00