Abstract：
:The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and bend DNA alone or with other proteins. Here we discuss our current knowledge on how Sox transcription factors such as Sox2, Sox17, Sox18 and Sox9 'read' the genome to find and regulate their target genes and highlight the roles of partner factors including Pax6, Nanog, Oct4 and Brn2. We integrate insights from structural and biochemical studies as well as high-throughput assays to probe DNA specificity in vitro as well as in cells and tissues.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Hou L,Srivastava Y,Jauch Rdoi
10.1016/j.semcdb.2016.08.005subject
Has Abstractpub_date
2017-03-01 00:00:00pages
2-12eissn
1084-9521issn
1096-3634pii
S1084-9521(16)30243-9journal_volume
63pub_type
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