Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration.

abstract：:Actin filaments (F-actin) are a key component of eukaryotic cells. Whether serving as a scaffold for myosin or using their polymerization to push onto cellular components, their function is always related to force generation. To control and fine-tune force production, cells have a large array of actin-binding proteins...

journal_title：Seminars in cell & developmental biology

authors： Merino F,Pospich S,Raunser S

更新日期：2020-06-01 00:00:00

abstract：:In recent years, novel functions for a number of nuclear factors have been uncovered in the cytoplasm, mainly at the level of translation. These factors behave as multifunctional regulators of gene expression and many play key roles in cell differentiation and development. One of the best characterized examples is tha...

journal_title：Seminars in cell & developmental biology

authors： Gebauer F,Merendino L,Hentze MW,Valcárcel J

更新日期：1997-12-01 00:00:00

abstract：:Dictyostelium cells are genetically haploid and therefore easily analyzed for mutant phenotypes. In the past, many tools and molecular markers have been developed for a quantitative and qualitative analysis of the endocytic pathway in these amoebae. This review outlines parallels and discrepancies between mutants in D...

journal_title：Seminars in cell & developmental biology

authors： Maniak M

更新日期：2011-02-01 00:00:00

abstract：:When entering tissues, monocytes can differentiate into cells that share morphological and functional features with either dendritic cells (DC) or macrophages. Monocyte-derived DC have been observed in humans at mucosal tissues and in inflammatory settings, where they are usually referred to as «inflammatory DC». In t...

journal_title：Seminars in cell & developmental biology

authors： Tang-Huau TL,Segura E

更新日期：2019-02-01 00:00:00

abstract：:Paramutation was initially described in maize and was defined as an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification of the other allele without modifying the DNA sequence [1,2]. Thus it implies that the paramutated allele conserves its new properties on ...

journal_title：Seminars in cell & developmental biology

authors： Ronsseray S

更新日期：2015-08-01 00:00:00

abstract：:Spatial patterns of neuronal connectivity are critical for neural circuit function and information processing. For many neuron types, the development of stereotyped dendritic and axonal territories involves reiterative contacts between neurites and successive re-calibration of branch outgrowth and directionality. Here...

journal_title：Seminars in cell & developmental biology

authors： Lefebvre JL

更新日期：2017-09-01 00:00:00

abstract：:TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become ...

journal_title：Seminars in cell & developmental biology

authors： Bagge J,Oestergaard VH,Lisby M

更新日期：2020-09-07 00:00:00

abstract：:Genomic instability resultant from defective DNA repair mechanisms is a fundamental hallmark of cancer. The poly(ADP-ribose) polymerase (PARP) proteins 1, 2 and 3 catalyze the polymerization of poly(ADP-ribose) and covalent attachment to proteins in a phylogenetically ancient form of protein modification. PARPs play a...

journal_title：Seminars in cell & developmental biology

authors： Dulaney C,Marcrom S,Stanley J,Yang ES

更新日期：2017-03-01 00:00:00

abstract：:Cellular morphogenesis is a complex process and molecular studies in the last few decades have amassed a large amount of information that is difficult to grasp in any completeness. Fungal systems, in particular the budding and fission yeasts, have been important players in unravelling the basic structural and regulato...

journal_title：Seminars in cell & developmental biology

authors： Wedlich-Soldner R,Li R

更新日期：2008-06-01 00:00:00

abstract：:Multiple myeloma is a bone marrow neoplasia with an incidence of 6/100,000/year in Europe. While the disease remains incurable, the development of novel treatments such as autologous stem cell transplantation, proteasome inhibitors and monoclonal antibodies has led to an increasing subset of patients living with long-...

journal_title：Seminars in cell & developmental biology

authors： Diaz-delCastillo M,Chantry AD,Lawson MA,Heegaard AM

更新日期：2020-11-03 00:00:00

abstract：:Hepatic oval cell activation, proliferation, and differentiation has been observed under certain physiological conditions, mainly when the proliferation of existing hepatocytes has been inhibited followed by severe hepatic injury. Hepatic oval cells display a distinct phenotype and have been shown to be a bipotential ...

journal_title：Seminars in cell & developmental biology

authors： Oh SH,Hatch HM,Petersen BE

更新日期：2002-12-01 00:00:00

abstract：:Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [...

journal_title：Seminars in cell & developmental biology

authors： Crow ET,Li L

更新日期：2011-07-01 00:00:00

abstract：:The vast amount of recent progress made on the sequence of the human genome has allowed an unprecedented examination of cis-regulatory networks. These networks consist of functional elements such as promoters, enhancers, silencers, and insulators, and their coordinated activity is responsible for regulation of gene ex...

journal_title：Seminars in cell & developmental biology

authors： Cecchini KR,Raja Banerjee A,Kim TH

更新日期：2009-09-01 00:00:00

abstract：:How limited is the ability of stem cells to generate gametes or differentiated somatic cells? Recent outcomes of research with stem cells from both embryonic and adult origin will be discussed with particular attention to results that challenge conventional wisdom about the presence of reproductive stem cells in adult...

journal_title：Seminars in cell & developmental biology

authors： McLean DJ

更新日期：2006-08-01 00:00:00

abstract：:In mammals, sex determination defines the differentiation of the bipotential genital ridge into either testes or ovaries. Sry, the mammalian Y-chromosomal testis-determining gene, is a master regulator of male sex determination. It acts to switch the undifferentiated genital ridge towards testis development, triggerin...

journal_title：Seminars in cell & developmental biology

authors： She ZY,Yang WX

更新日期：2017-03-01 00:00:00

abstract：:Mature skeletal muscle forms from the fusion of skeletal muscle precursor cells, myoblasts. Myoblasts fuse to other myoblasts to generate multinucleate myotubes during myogenesis, and myoblasts also fuse to other myotubes during muscle growth and repair. Proteins within myoblasts and myotubes regulate complex processe...

journal_title：Seminars in cell & developmental biology

authors： Demonbreun AR,Biersmith BH,McNally EM

更新日期：2015-09-01 00:00:00

abstract：:The immune system plays an indispensable role in the process of tissue regeneration following damage as well as during homeostasis. Inflammation and immune cell recruitment are signs of early onset injury. At the wound site, immune cells not only help to clear debris but also secrete numerous signalling molecules that...

journal_title：Seminars in cell & developmental biology

authors： Abnave P,Ghigo E

更新日期：2019-03-01 00:00:00

abstract：:The localisation of transcripts to specific regions of the cell probably occurs in all cell types and has many distinct functions that go from the control of body axis formation to learning and memory. mRNAs can be localised by a variety of mechanisms including local protection from degradation, diffusion to a localis...

journal_title：Seminars in cell & developmental biology

authors： Palacios IM

更新日期：2007-04-01 00:00:00

abstract：:The formation of ovules is a key step in the plant life cycle which alternates between a diploid and haploid generation, the sporophyte and the gametophyte. The transitions between the two generations in the female occur in the ovule, the site of meiosis, female gametogenesis and double fertilization. The intimate ass...

journal_title：Seminars in cell & developmental biology

authors： Grossniklaus U,Schneitz K

更新日期：1998-04-01 00:00:00

abstract：:The use of the adapted models to decipher patho-physiological mechanisms of human diseases is always a great challenge. This is of particular importance for early-onset myopathies, in which pathological mutations often impact not only on muscle structure and function but also on developmental processes. Mice are curre...

journal_title：Seminars in cell & developmental biology

authors： Jagla K,Kalman B,Boudou T,Hénon S,Batonnet-Pichon S

更新日期：2017-04-01 00:00:00

abstract：:Most mammals cannot easily overcome degenerative disease or traumatic injuries. In contrast, an innate ability to regenerate is observed across animal phyla. Freshwater planarians are amongst the organisms that are capable of stem cell-mediated whole-body regeneration and have served as an exemplary model to study how...

journal_title：Seminars in cell & developmental biology

authors： Strand NS,Allen JM,Zayas RM

更新日期：2019-03-01 00:00:00

abstract：:At fertilisation, Ca(2+) signals activate embryonic development by stimulating metabolism, exocytosis and endocytosis, cytoskeletal remodelling, meiotic resumption and recruitment of maternal RNAs. Mitochondria present in large number in eggs have long been thought to act as a relay in Ca(2+) signalling at fertilisati...

journal_title：Seminars in cell & developmental biology

authors： Dumollard R,Duchen M,Sardet C

更新日期：2006-04-01 00:00:00

abstract：:The exchange of substances between metazoan and the environment takes place across transporting epithelia that have two fundamental differentiated features: tight junctions (TJ) and apical/basolateral polarity. Usually, reviews of the structure and function of transporting epithelia follow a historical description of ...

journal_title：Seminars in cell & developmental biology

authors： Larre I,Ponce A,Franco M,Cereijido M

更新日期：2014-12-01 00:00:00

abstract：:Cell signaling is essential for cells to adequately respond to their environment. One of the most evolutionarily conserved signaling pathways is that of the epidermal growth factor receptor (EGFR). Transmembrane receptors with intracellular tyrosine kinase activity are activated by the binding of their corresponding l...

journal_title：Seminars in cell & developmental biology

authors： Barberán S,Cebrià F

更新日期：2019-03-01 00:00:00

abstract：:Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinat...

journal_title：Seminars in cell & developmental biology

authors： Depino AM

更新日期：2018-05-01 00:00:00

abstract：:Biological tubes are a prevalent structural design across living organisms. They provide essential functions during the development and adult life of an organism. Increasing progress has been made recently in delineating the cellular and molecular mechanisms underlying tubulogenesis. This review aims to introduce asci...

journal_title：Seminars in cell & developmental biology

authors： Denker E,Jiang D

更新日期：2012-05-01 00:00:00

abstract：:Carotenoids are an important source of metabolites with regulatory function, which include the plant hormones abscisic acid (ABA) and strigolactones (SLs), and several recently identified growth regulators and signaling molecules. These carotenoid-derivatives originate from oxidative breakdown of double bonds in the c...

journal_title：Seminars in cell & developmental biology

authors： Wang JY,Lin PY,Al-Babili S

更新日期：2020-07-27 00:00:00

abstract：:Growth factors acting through receptor tyrosine kinases (RTKs) of ERBB family, along with steroid hormones (SH) acting through nuclear receptors (NRs), are critical signalling mediators of cellular processes. Deregulations of ERBB and steroid hormone receptors are responsible for several diseases, including cancer, th...

journal_title：Seminars in cell & developmental biology

authors： D'Uva G,Lauriola M

更新日期：2016-02-01 00:00:00

abstract：:The developmental processes that give rise to the animal body plan are exceedingly complex. Model systems such as Drosophila melanogaster have yielded profound insight into roles of conserved genes and genetic pathways in development. Drosophila development begins with the formation of sperm and eggs, and proceeds thr...

journal_title：Seminars in cell & developmental biology

authors： Mason DA,Goldfarb DS

更新日期：2009-07-01 00:00:00

abstract：:There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hur...

journal_title：Seminars in cell & developmental biology

authors： Kind A,Colman A

更新日期：1999-06-01 00:00:00