Abstract：
:Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction. A population of stem and progenitor cells known as undifferentiated spermatogonia enables continual spermatogenesis throughout life. A complex transcriptional network that balances self-renewal of spermatogonia with their timely differentiation in order to maintain constant fertility regulates this process. Importantly, post-transcriptional regulation of gene expression plays a critical role in spermatogenesis, necessitated by the profound genetic and morphological changes that occur during meiosis and sperm maturation. Pre-mRNA splicing, mRNA export, maintenance of transcript stability and translation are key RNA processing steps that are regulated in the male germline to maintain coordinated gene expression. In this review, we examine these processes in the context of mammalian spermatogenesis and provide an overview of key mediators at each step.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Legrand JMD,Hobbs RMdoi
10.1016/j.semcdb.2017.10.006subject
Has Abstractpub_date
2018-07-01 00:00:00pages
80-91eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30141-6journal_volume
79pub_type
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