Abstract：
:Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular model for the barcoding mechanism. Protocadherin isoforms assemble into promiscuous cis-dimeric recognition units and mediate cell-cell recognition through homophilic trans-interactions. Each recognition unit is composed of two arms extending from the membrane proximal EC6 domains. A cis-dimeric recognition unit with each arm coding adhesive trans homophilic specificity can generate a zipper-like assembly that in turn suggests a chain termination mechanism for self-vs-non-self-discrimination among vertebrate neurons.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Rubinstein R,Goodman KM,Maniatis T,Shapiro L,Honig Bdoi
10.1016/j.semcdb.2017.07.023subject
Has Abstractpub_date
2017-09-01 00:00:00pages
140-150eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30408-1journal_volume
69pub_type
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