Abstract:
:The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. The major components of the BM are collagen IV, laminins, heparan sulfate proteoglycans and nidogen and also associated proteins such as collagen XVIII and fibronectin. Their organization and scaffolding in the BM is required for proper capillary morphogenesis and maintenance of vascular homeostasis. The BM also regulates vascular mechanosensing. A better understanding of the mechanical and structural properties of the vascular BM and interstitial ECM therefore opens new perspectives to control physiological and pathological angiogenesis and vascular homeostasis. The overall aim of this review is to explain how ECM scaffolding influences angiogenesis and capillary integrity.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Marchand M,Monnot C,Muller L,Germain Sdoi
10.1016/j.semcdb.2018.08.007subject
Has Abstractpub_date
2019-05-01 00:00:00pages
147-156eissn
1084-9521issn
1096-3634pii
S1084-9521(17)30578-5journal_volume
89pub_type
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