Hypoxia-inducible factors: crosstalk between inflammation and metabolism.

abstract：:The purpose of this review is to describe the endocrine and local testicular factors that contribute to the regulation of the blood-testis barrier (BTB), using information gained from in vivo and in vitro models of BTB formation during/after puberty, and from the maintenance of BTB function during adulthood. In vivo t...

journal_title：Seminars in cell & developmental biology

authors： Stanton PG

更新日期：2016-11-01 00:00:00

abstract：:Two neurotrophins and their two receptors appear to regulate the survival of vestibular and cochlear neurons in the developing ear. Mice lacking either brain derived neurotrophic factor (BDNF) or its associated receptor, Trk B, show a severe reduction in the number of vestibular neurons and a loss of all innervation t...

journal_title：Seminars in cell & developmental biology

authors： Fritzsch B,Silos-Santiago I,Bianchi LM,Farinas I

更新日期：1997-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) was originally discovered as an endothelial-specific growth factor. While the predominant role of this growth factor in the formation of new blood vessels (angiogenesis) is unquestioned, recent observations indicate that VEGF also has direct effects on neurons and glial cells,...

journal_title：Seminars in cell & developmental biology

authors： Carmeliet P,Storkebaum E

更新日期：2002-02-01 00:00:00

abstract：:Since the identification of a metazoan counterpart to yeast Mediator nearly 15 years ago, a convergent body of biochemical and molecular genetic studies have confirmed their structural and functional relationship as an integrative hub through which regulatory information conveyed by signal activated transcription fact...

journal_title：Seminars in cell & developmental biology

authors： Spaeth JM,Kim NH,Boyer TG

更新日期：2011-09-01 00:00:00

abstract：:The Drosophila heart, also called the dorsal vessel, is a linear tube consisting of two major cell types, namely cardioblasts which serve as cardiomyocytes and pericardial cells which surround its outer surface. This organ is derived from segmental clusters of cells in the dorsal mesoderm during early embryonic develo...

journal_title：Seminars in cell & developmental biology

authors： Frasch M

更新日期：1999-02-01 00:00:00

abstract：:Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominan...

journal_title：Seminars in cell & developmental biology

authors： Mandalos NP,Remboutsika E

更新日期：2017-03-01 00:00:00

abstract：:Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Galpha-subunits. At least some can also influence Galpha activity through either effector antagonism or by acting as guanine nucleotide dissociation inh...

journal_title：Seminars in cell & developmental biology

authors： Willars GB

更新日期：2006-06-01 00:00:00

abstract：:The primary cilium is a cellular antenna found on the surface of many eukaryotic cells, whose main role is to sense and transduce signals that regulate growth, development, and differentiation. Although once believed to be a vestigial organelle without important function, it has become clear that defects in primary ci...

journal_title：Seminars in cell & developmental biology

authors： Hossain D,Tsang WY

更新日期：2019-09-01 00:00:00

abstract：:During vertebrate gastrulation, large cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish offer many genetic and experimental advantages for studying vertebrate gastrulation movements. For instance, several mutants, including silberblick, knypek and trilob...

journal_title：Seminars in cell & developmental biology

authors： Heisenberg CP,Tada M

更新日期：2002-12-01 00:00:00

abstract：:Modification of histone amino terminal tails by acetylation has long been linked to the transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics. Over the last few years a flurry of reports have described the purification and identification of a large number of histone acetyltransfer...

journal_title：Seminars in cell & developmental biology

authors： Grant PA,Berger SL

更新日期：1999-04-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.1016/j.semcdb.2013.05.010. The duplicate article has therefore been withdrawn. ...

journal_title：Seminars in cell & developmental biology

authors： Lopez-Vernaza MA,Leach DR

更新日期：2013-05-18 00:00:00

abstract：:Embryonic patterning of the mouse during gastrulation and early organogenesis engenders the specification of anterior versus posterior structures and body laterality by the interaction of signalling and modulating activities. A group of cells in the mouse gastrula, characterised by the expression of a repertoire of "o...

journal_title：Seminars in cell & developmental biology

authors： Robb L,Tam PP

更新日期：2004-10-01 00:00:00

abstract：:The mechanistic (or mammalian) Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth and metabolism. By integrating mitogenic signals, mTORC1-dependent phosphorylation of substrates dictates the balance between anabolic, pro-growth and catabolic, recycling processes in the cell. The discovery th...

journal_title：Seminars in cell & developmental biology

authors： Carroll B

更新日期：2020-11-01 00:00:00

abstract：:Polycomb group (PcG) proteins play essential roles in animal and plant life cycles by controlling the expression of important developmental regulators. These structurally heterogeneous proteins form multimeric protein complexes that control higher order chromatin structure and, thereby, the expression state of their t...

journal_title：Seminars in cell & developmental biology

authors： Reyes JC,Grossniklaus U

更新日期：2003-02-01 00:00:00

abstract：:Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...

journal_title：Seminars in cell & developmental biology

authors： Popa SJ,Stewart SE,Moreau K

更新日期：2018-11-01 00:00:00

abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...

journal_title：Seminars in cell & developmental biology

authors： Campàs O

更新日期：2016-07-01 00:00:00

abstract：:A wide range of cellular activities including protein folding and cell secretion, such as neurotransmission or insulin release, are all governed by intracellular pH homeostasis, underscoring the importance of pH on critical life processes. Nano- scale pH measurements of cells and biomolecules therefore hold great prom...

journal_title：Seminars in cell & developmental biology

authors： Lewis KT,Naik AR,Laha SS,Wang S,Mao G,Kuhn E,Jena BP

更新日期：2018-01-01 00:00:00

abstract：:Over two decades, γ-secretase has been the target for extensive therapeutic development due to its pivotal role in pathogenesis of Alzheimer's disease and cancer. However, it has proven to be a challenging task owing to its large set of substrates and our limited understanding of the enzyme's structural and mechanisti...

journal_title：Seminars in cell & developmental biology

authors： Nie P,Vartak A,Li YM

更新日期：2020-09-01 00:00:00

abstract：:One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through d...

journal_title：Seminars in cell & developmental biology

authors： Lee YL,Burke B

更新日期：2018-10-01 00:00:00

abstract：:The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membra...

journal_title：Seminars in cell & developmental biology

authors： Granger E,McNee G,Allan V,Woodman P

更新日期：2014-07-01 00:00:00

abstract：:β cells uniquely produce and secrete insulin under the control of several, integrated signals, to maintain blood glucose concentrations within a narrow physiological interval. β cell failure is key to the onset and progression of type 2 diabetes, due to impaired function and reduced mass. In this review we focus on se...

journal_title：Seminars in cell & developmental biology

authors： Marchetti P,Suleiman M,De Luca C,Baronti W,Bosi E,Tesi M,Marselli L

更新日期：2020-07-01 00:00:00

abstract：:Eph receptor tyrosine kinases mediate cell-cell communication by interacting with ephrin ligands residing on adjacent cell surfaces. In doing so, these juxtamembrane signaling complexes provide important contextual information about the cellular microenvironment that helps orchestrate tissue morphogenesis and maintain...

journal_title：Seminars in cell & developmental biology

authors： Lin S,Wang B,Getsios S

更新日期：2012-02-01 00:00:00

abstract：:Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...

journal_title：Seminars in cell & developmental biology

authors： Wang Y,Li L,Hou C,Lai Y,Long J,Liu J,Zhong Q,Diao J

更新日期：2016-12-01 00:00:00

abstract：:Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-da...

journal_title：Seminars in cell & developmental biology

authors： Serlin Y,Shelef I,Knyazer B,Friedman A

更新日期：2015-02-01 00:00:00

abstract：:Any type of tubulogenesis is a process that is highly coordinated between large numbers of cells. Like other morphogenetic processes, it is driven to a great extent by complex cell shape changes and cell rearrangements. The formation of the salivary glands in the fly embryo provides an ideal model system to study thes...

journal_title：Seminars in cell & developmental biology

authors： Girdler GC,Röper K

更新日期：2014-07-01 00:00:00

abstract：:Demyelinating disorders of the central white matter are among the most prevalent and disabling conditions in neurology. Since myelin-producing oligodendrocytes comprise the principal cell type deficient or lost in these conditions, their replacement by new cells generated from transplanted bipotential oligodendrocyte-...

journal_title：Seminars in cell & developmental biology

authors： Goldman SA,Mariani JN,Madsen PM

更新日期：2021-01-04 00:00:00

abstract：:The proinflammatory cytokine tumor necrosis factor (TNF) orchestrates complex multicellular processes through a wide variety of changes that it induces in cell functions. At various stages of the study of TNF, attention has been drawn to one of three different modes of its action. The work that led to the discovery of...

journal_title：Seminars in cell & developmental biology

authors： Wallach D

更新日期：2016-02-01 00:00:00

abstract：:Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions...

journal_title：Seminars in cell & developmental biology

authors： Kim M,Bjorke B,Mastick GS

更新日期：2019-01-01 00:00:00

abstract：:Hypoxic exposure of cells or organisms induces expression of a number of hypoxia responsive genes through the activation of the hypoxia-inducible factor-1 (HIF-1). One of the most prominent HIF-1 targets is erythropoietin that has beneficial effects on ischemia-related injury in the brain. Exposure to low environmenta...

journal_title：Seminars in cell & developmental biology

authors： Grimm C,Hermann DM,Bogdanova A,Hotop S,Kilic U,Wenzel A,Kilic E,Gassmann M

更新日期：2005-08-01 00:00:00

abstract：:Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinat...

journal_title：Seminars in cell & developmental biology

authors： Depino AM

更新日期：2018-05-01 00:00:00