Abstract：
:Multivesicular bodies (MVBs) are ubiquitous endocytic organelles containing numerous 50-80 nm vesicles. MVBs are very dynamic in shape and function. In antigen presenting cells (APCs), MVBs play a central role in the loading of major histocompatibility complex class II (MHC II) with antigenic peptides. How MHC II is transported from MVBs to the cell surface is only partly understood. One way involves direct fusion of MVBs with the plasma membrane. As a consequence, their internal vesicles are secreted as so-called exosomes. An alternative has been illustrated in maturing dendritic cells (DCs). Here, MVBs are reshaped into long tubules by back fusion of the internal vesicles with the MVB limiting membrane. Vesicles derived from the tips of these tubules then carry MHC II to the cell surface.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Murk JL,Stoorvogel W,Kleijmeer MJ,Geuze HJdoi
10.1016/s1084952102000605subject
Has Abstractpub_date
2002-08-01 00:00:00pages
303-11issue
4eissn
1084-9521issn
1096-3634pii
S1084-9521(02)00060-5journal_volume
13pub_type
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