Abstract:
:The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Conaway RC,Conaway JWdoi
10.1016/j.semcdb.2011.07.021subject
Has Abstractpub_date
2011-09-01 00:00:00pages
729-34issue
7eissn
1084-9521issn
1096-3634pii
S1084-9521(11)00109-1journal_volume
22pub_type
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