Abstract：
:Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the critical physiological functions accomplished by the transport of lymph, a complete understanding of the contractile machinery of the lymphatic system lags far behind that of the blood vasculature. However, there has been a surge of recent research focusing on different mechanisms that underlie both physiological and pathophysiological aspects of lymphatic contractile function. This review summarizes those emerging paradigms that shed some novel insights into the contractile physiology of the lymphatics in normal as well as different disease states. In addition, this review emphasizes the recent progress made in our understanding of various contractile parameters and regulatory elements that contribute to the normal functioning of the lymphatics.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Chakraborty S,Davis MJ,Muthuchamy Mdoi
10.1016/j.semcdb.2015.01.005subject
Has Abstractpub_date
2015-02-01 00:00:00pages
55-66eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00007-5journal_volume
38pub_type
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