Abstract:
:Vascular endothelial growth factor (VEGF) was originally discovered as an endothelial-specific growth factor. While the predominant role of this growth factor in the formation of new blood vessels (angiogenesis) is unquestioned, recent observations indicate that VEGF also has direct effects on neurons and glial cells, and stimulates their growth, survival and axonal outgrowth. Because of these pleiotropic effects, VEGF has now been implicated in several neurological disorders both in the preterm infant (leukomalacia) and the adult (stroke, neurodegeneration, cerebral and spinal trauma, ischemic and diabetic neuropathy, nerve regeneration). A challenge for the future is to unravel to what extent the effect of VEGF in these disorders relates to its angiogenic activity or direct neurotrophic effect.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Carmeliet P,Storkebaum Edoi
10.1006/scdb.2001.0290subject
Has Abstractpub_date
2002-02-01 00:00:00pages
39-53issue
1eissn
1084-9521issn
1096-3634pii
S1084-9521(01)90290-3journal_volume
13pub_type
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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journal_title:Seminars in cell & developmental biology
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abstract::Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...
journal_title:Seminars in cell & developmental biology
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