Abstract：
:The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of other proteins to these sites. What is less clear is whether claudins form the paracellular seal. While this seal is defective when claudins are disrupted, some results, including ultrastructural and biochemical data, suggest that lipid structures are an important component of tight junction strands and may be responsible for the paracellular seal. This review highlights current understanding of claudin contributions to barrier function and tight junction structure and suggests a model by which claudins and other tight junction proteins can drive assembly and stabilization of a lipid-based strand structure.
journal_name
Semin Cell Dev Bioljournal_title
Seminars in cell & developmental biologyauthors
Lingaraju A,Long TM,Wang Y,Austin JR 2nd,Turner JRdoi
10.1016/j.semcdb.2015.04.008subject
Has Abstractpub_date
2015-06-01 00:00:00pages
13-21eissn
1084-9521issn
1096-3634pii
S1084-9521(15)00094-4journal_volume
42pub_type
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