解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19020067
更新日期:2021-01-27 00:00:00
abstract::In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19020050
更新日期:2021-01-22 00:00:00
abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19010008
更新日期:2020-12-27 00:00:00
abstract::Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19010003
更新日期:2020-12-23 00:00:00
abstract::In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120660
更新日期:2020-12-21 00:00:00
abstract::Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for comple...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120631
更新日期:2020-12-10 00:00:00
abstract::Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120626
更新日期:2020-12-08 00:00:00
abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120622
更新日期:2020-12-07 00:00:00
abstract::The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120613
更新日期:2020-12-02 00:00:00
abstract::Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120604
更新日期:2020-11-29 00:00:00
abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120594
更新日期:2020-11-26 00:00:00
abstract::Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110567
更新日期:2020-11-19 00:00:00
abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110561
更新日期:2020-11-17 00:00:00
abstract::In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110556
更新日期:2020-11-07 00:00:00
abstract::Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110536
更新日期:2020-10-28 00:00:00
abstract::During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110525
更新日期:2020-10-23 00:00:00
abstract::Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100521
更新日期:2020-10-19 00:00:00
abstract::Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100517
更新日期:2020-10-16 00:00:00
abstract::The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100515
更新日期:2020-10-14 00:00:00
abstract::Two new nitrogen-containing metabolites, designated hatsusamide A (1) and B (2), were isolated from a culture broth of Penicilliumsteckii FKJ-0213 together with the known compounds tanzawaic acid B (3) and trichodermamide C (4) by physicochemical (PC) screening. The structures of 1 and 2 were determined as a tanzawaic...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100513
更新日期:2020-10-12 00:00:00
abstract::It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100488
更新日期:2020-09-25 00:00:00
abstract::Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18090471
更新日期:2020-09-18 00:00:00
abstract::A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090465
更新日期:2020-09-14 00:00:00
abstract::Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090454
更新日期:2020-08-30 00:00:00
abstract::The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090433
更新日期:2020-08-19 00:00:00
abstract::When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080419
更新日期:2020-08-10 00:00:00
abstract::Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized. We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus la...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080407
更新日期:2020-08-01 00:00:00
abstract::Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080389
更新日期:2020-07-27 00:00:00
abstract::Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080384
更新日期:2020-07-24 00:00:00
abstract::Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080379
更新日期:2020-07-22 00:00:00
abstract::The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18070366
更新日期:2020-07-16 00:00:00
abstract::Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18070349
更新日期:2020-07-03 00:00:00
abstract::A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extrac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18070336
更新日期:2020-06-27 00:00:00
abstract::Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18060335
更新日期:2020-06-26 00:00:00
abstract::The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18060327
更新日期:2020-06-23 00:00:00
abstract::Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18040228
更新日期:2020-04-24 00:00:00
abstract::This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040226
更新日期:2020-04-24 00:00:00
abstract::The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040218
更新日期:2020-04-17 00:00:00
abstract::Dysregulation of the Wnt/β-catenin signaling pathway is involved in the development of human hepatocellular carcinoma and has thus emerged as a therapeutic target for this malignant tumor. In this study, we employed sensitive cell-based assays to identify aplykurodin A isolated from Aplysia kurodai as an antagonist of...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040210
更新日期:2020-04-13 00:00:00
abstract::Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18040190
更新日期:2020-04-02 00:00:00