Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.


:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.


Mar Drugs


Marine drugs


Park JS,Cho E,Hwang JY,Park SC,Chung B,Kwon OS,Sim CJ,Oh DC,Oh KB,Shin J




Has Abstract


2020-12-23 00:00:00










  • Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities.

    abstract::Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQ

    更新日期:2013-12-02 00:00:00

  • The Mucus of Actinia equina (Anthozoa, Cnidaria): An Unexplored Resource for Potential Applicative Purposes.

    abstract::The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Stabili L,Schirosi R,Parisi MG,Piraino S,Cammarata M

    更新日期:2015-08-19 00:00:00

  • Influence of Preparation Methods of Chitooligosaccharides on Their Physicochemical Properties and Their Anti-Inflammatory Effects in Mice and in RAW264.7 Macrophages.

    abstract::The methods to obtain chitooligosaccharides are tightly related to the physicochemical properties of the end products. Knowledge of these physicochemical characteristics is crucial to describing the biological functions of chitooligosaccharides. Chitooligosaccharides were prepared either in a single-step enzymatic hyd...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sánchez Á,Mengíbar M,Fernández M,Alemany S,Heras A,Acosta N

    更新日期:2018-11-02 00:00:00

  • Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity.

    abstract::Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati O

    更新日期:2013-08-28 00:00:00

  • The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

    abstract::Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

    更新日期:2018-06-25 00:00:00

  • High-Throughput Identification and Analysis of Novel Conotoxins from Three Vermivorous Cone Snails by Transcriptome Sequencing.

    abstract::The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative conotoxin transcripts from the venom ducts of 3 vermivorous cone sna...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yao G,Peng C,Zhu Y,Fan C,Jiang H,Chen J,Cao Y,Shi Q

    更新日期:2019-03-26 00:00:00

  • Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum).

    abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ngokpol S,Suwakulsiri W,Sureram S,Lirdprapamongkol K,Aree T,Wiyakrutta S,Mahidol C,Ruchirawat S,Kittakoop P

    更新日期:2015-06-05 00:00:00

  • Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation.

    abstract::Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: García F,Lobos P,Ponce A,Cataldo K,Meza D,Farías P,Estay C,Oyarzun-Ampuero F,Herrera-Molina R,Paula-Lima A,Ardiles ÁO,Hidalgo C,Adasme T,Muñoz P

    更新日期:2020-06-26 00:00:00

  • Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells.

    abstract::A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Choi BK,Jo SH,Choi DK,Trinh PTH,Lee HS,Cao VA,Van TTT,Shin HJ

    更新日期:2020-09-14 00:00:00

  • Natural product research in the Australian marine invertebrate Dicathais orbita.

    abstract::The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Benkendorff K

    更新日期:2013-04-23 00:00:00

  • Structures and Bioactivities of Psolusosides B1, B2, J, K, L, M, N, O, P, and Q from the Sea Cucumber Psolus fabricii. The First Finding of Tetrasulfated Marine Low Molecular Weight Metabolites.

    abstract::Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Popov RS,Chingizova EA

    更新日期:2019-11-06 00:00:00

  • Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.

    abstract::To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

    更新日期:2019-07-26 00:00:00

  • Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products.

    abstract::A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

    更新日期:2018-12-20 00:00:00

  • Suberitamides A-C, Aryl Alkaloids from a Pseudosuberites sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity.

    abstract::Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim CK,Wang D,Wilson BAP,Saurí J,Voeller D,Lipkowitz S,O'Keefe BR,Gustafson KR

    更新日期:2020-10-28 00:00:00

  • Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.

    abstract::Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Maoka T,Tokuda H,Suzuki N,Kato H,Etoh H

    更新日期:2012-06-01 00:00:00

  • Synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and its inhibition of liver cancer characteristics in vitro and in vivo.

    abstract::Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng M,Gao X,Wang Y,Chen H,He B,Xu H,Li Y,Han J,Zhang Z

    更新日期:2013-09-17 00:00:00

  • Diphlorethohydroxycarmalol Attenuates Fine Particulate Matter-Induced Subcellular Skin Dysfunction.

    abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhen AX,Piao MJ,Hyun YJ,Kang KA,Madushan Fernando PDS,Cho SJ,Ahn MJ,Hyun JW

    更新日期:2019-02-01 00:00:00

  • Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos.

    abstract::Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lopes VR,Fernández N,Martins RF,Vasconcelos V

    更新日期:2010-03-05 00:00:00

  • The Marine Fungi Rhodotorula sp. (Strain CNYC4007) as a Potential Feed Source for Fish Larvae Nutrition.

    abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Barra M,Llanos-Rivera A,Cruzat F,Pino-Maureira N,González-Saldía RR

    更新日期:2017-12-01 00:00:00

  • Water-Soluble Fish Protein Intake Led to Lower Serum and Liver Cholesterol Concentrations in Obese Zucker fa/fa Rats.

    abstract::Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OA

    更新日期:2018-05-01 00:00:00

  • Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

    abstract::Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhang W,Sun T,Ma Z,Li Y

    更新日期:2014-04-22 00:00:00

  • NMR-based metabolomic analysis of spatial variation in soft corals.

    abstract::Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: He Q,Sun R,Liu H,Geng Z,Chen D,Li Y,Han J,Lin W,Du S,Deng Z

    更新日期:2014-03-28 00:00:00

  • Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei.

    abstract::In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Youssef DT,Shaala LA,Mohamed GA,Badr JM,Bamanie FH,Ibrahim SR

    更新日期:2014-04-01 00:00:00

  • Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice.

    abstract::Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exe...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ni X,Yu H,Wang S,Zhang C,Shen S

    更新日期:2017-03-08 00:00:00

  • Impact of ocean acidification on energy metabolism of oyster, Crassostrea gigas--changes in metabolic pathways and thermal response.

    abstract::Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lannig G,Eilers S,Pörtner HO,Sokolova IM,Bock C

    更新日期:2010-08-11 00:00:00

  • Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats.

    abstract::Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh JH,Choi JS,Nam TJ

    更新日期:2018-10-05 00:00:00

  • New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum.

    abstract::Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gutiérrez M,Santamaría R,Gómez-Reyes JF,Guzmán HM,Ávila-Román J,Motilva V,Talero E

    更新日期:2020-01-27 00:00:00

  • Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo.

    abstract::Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang Y,Zhang X,Yang Y,Yang X,Ye B

    更新日期:2015-08-18 00:00:00

  • Cultivation of Sponge-Associated Bacteria from Agelas sventres and Xestospongia muta Collected from Different Depths.

    abstract::Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

    更新日期:2019-10-11 00:00:00

  • Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

    abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

    更新日期:2014-07-08 00:00:00