Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

Abstract:

:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Park JS,Cho E,Hwang JY,Park SC,Chung B,Kwon OS,Sim CJ,Oh DC,Oh KB,Shin J

doi

10.3390/md19010003

subject

Has Abstract

pub_date

2020-12-23 00:00:00

issue

1

issn

1660-3397

pii

md19010003

journal_volume

19

pub_type

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