Abstract:
:During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and ceratinamine (6). The structural assignments of 1-6 were accomplished by interpretation of their NMR and HRESIMS spectral data. Pseudoceratonic acid possesses a dibrominated hydrazine-derived functional group not found in any reported chemical compound. Pseudoceratonic acid selectively inhibited the growth of E. coli and S. aureus, while ceratinine N selectively inhibited C. albicans. Further, ceratinine N showed potent cytotoxic effects against the triple-negative breast cancer, colorectal carcinoma, and human cervical carcinoma cell lines down to 2.1 µM.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Shaala LA,Youssef DTAdoi
10.3390/md18110525subject
Has Abstractpub_date
2020-10-23 00:00:00issue
11issn
1660-3397pii
md18110525journal_volume
18pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030093
更新日期:2018-03-13 00:00:00
abstract::Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080389
更新日期:2020-07-27 00:00:00
abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md10050963
更新日期:2012-05-01 00:00:00
abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10030639
更新日期:2012-03-01 00:00:00
abstract::Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low t...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14110205
更新日期:2016-11-03 00:00:00
abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074110
更新日期:2014-07-08 00:00:00
abstract::In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8040916
更新日期:2010-03-29 00:00:00
abstract::Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator to...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090269
更新日期:2017-08-30 00:00:00
abstract::Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11124788
更新日期:2013-12-02 00:00:00
abstract::Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110441
更新日期:2018-11-09 00:00:00
abstract::Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10061391
更新日期:2012-06-01 00:00:00
abstract::Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110350
更新日期:2017-11-07 00:00:00
abstract::The marine genus Pseudoalteromonas is known for its versatile biotechnological potential with respect to the production of antimicrobials and enzymes of industrial interest. We have sequenced the genomes of three Pseudoalteromonas sp. strains isolated from different deep sea sponges on the Illumina MiSeq platform. The...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060184
更新日期:2017-06-19 00:00:00
abstract::Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020096
更新日期:2020-01-31 00:00:00
abstract::Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070122
更新日期:2016-06-27 00:00:00
abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120622
更新日期:2020-12-07 00:00:00
abstract::Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030185
更新日期:2019-03-20 00:00:00
abstract::It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100488
更新日期:2020-09-25 00:00:00
abstract::Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110596
更新日期:2019-10-23 00:00:00
abstract::Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110614
更新日期:2019-10-29 00:00:00
abstract::PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050248
更新日期:2019-04-26 00:00:00
abstract:BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15030074
更新日期:2017-03-15 00:00:00
abstract::To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16080263
更新日期:2018-08-01 00:00:00
abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10112596
更新日期:2012-11-21 00:00:00
abstract::Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this dr...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100385
更新日期:2018-10-15 00:00:00
abstract::In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116609
更新日期:2015-10-28 00:00:00
abstract::Nostosins A and B were isolated from a hydrophilic extract of Nostoc sp. strain from Iran, which exhibits excellent tryps inhibitory activity. Nostosin A was the most potent natural tripeptide aldehyde as trypsin inhibitor up to now. Both R- and S-2-hydroxy-4-(4-hydroxy-phenyl) butanoic acid (Hhpba) were prepared and ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15030058
更新日期:2017-02-27 00:00:00
abstract::In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15050140
更新日期:2017-05-18 00:00:00
abstract::Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12042308
更新日期:2014-04-22 00:00:00
abstract::When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080419
更新日期:2020-08-10 00:00:00