Abstract：
:Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for complement-targeted therapeutics development. Arenicins from the sea polychaete Arenicola marina, the classical example of peptides with a β-hairpin structure stabilized by a disulfide bond, were shown earlier to be among the most prospective regulators. Here, we investigate the link between arenicins' structure and their antimicrobial, hemolytic and complement-modulating activities using the derivative Ar-1-(C/A) without a disulfide bond. Despite the absence of this bond, the peptide retains all important functional activities and also appears less hemolytic in comparison with the natural forms. These findings could help to investigate new complement drugs for regulation using arenicin derivatives.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Krenev IA,Umnyakova ES,Eliseev IE,Dubrovskii YA,Gorbunov NP,Pozolotin VA,Komlev AS,Panteleev PV,Balandin SV,Ovchinnikova TV,Shamova OV,Berlov MNdoi
10.3390/md18120631subject
Has Abstractpub_date
2020-12-10 00:00:00issue
12issn
1660-3397pii
md18120631journal_volume
18pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110567
更新日期：2020-11-19 00:00:00
abstract：:The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12042164
更新日期：2014-04-10 00:00:00
abstract：:To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100379
更新日期：2018-10-10 00:00:00
abstract：:Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110424
更新日期：2018-11-01 00:00:00
abstract：:A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13010128
更新日期：2014-12-29 00:00:00
abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070219
更新日期：2017-07-11 00:00:00
abstract：:Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030064
更新日期：2017-03-04 00:00:00
abstract：UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...
journal_title：Marine drugs
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3390/md10092047
更新日期：2012-09-01 00:00:00
abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030144
更新日期：2019-03-01 00:00:00
abstract：:D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7010045
更新日期：2009-01-01 00:00:00
abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110413
更新日期：2018-10-27 00:00:00
abstract：:Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18090471
更新日期：2020-09-18 00:00:00
abstract：:Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020063
更新日期：2018-02-15 00:00:00
abstract：:The small-spotted catshark is one of the most abundant elasmobranchs in the Northeastern Atlantic Ocean. Although its landings are devoted for human consumption, in general this species has low commercial value with high discard rates, reaching 100% in some European fisheries. The reduction of post-harvest losses (dis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010040
更新日期：2019-01-09 00:00:00
abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020084
更新日期：2019-02-01 00:00:00
abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080472
更新日期：2019-08-15 00:00:00
abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15110354
更新日期：2017-11-10 00:00:00
abstract：:Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110639
更新日期：2019-11-13 00:00:00
abstract：:Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14040078
更新日期：2016-04-13 00:00:00
abstract：:Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13041647
更新日期：2015-03-25 00:00:00
abstract：:The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100515
更新日期：2020-10-14 00:00:00
abstract：:The marine habitat provides a large number of structurally-diverse bioactive compounds for drug development. Marine sponges have been studied over many years and are found to be a rich source of these bioactive chemicals. This study is focused on the evaluation of the activity of six diterpene derivatives isolated fro...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12020700
更新日期：2014-01-27 00:00:00
abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040104
更新日期：2018-03-26 00:00:00
abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13053103
更新日期：2015-05-19 00:00:00
abstract：:The ability to produce an extracellular matrix and form multicellular communities is an adaptive behavior shared by many bacteria. In Bacillus subtilis, the model system for spore-forming bacteria, matrix production is one of the possible differentiation pathways that a cell can follow when vegetative growth is no lon...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13106472
更新日期：2015-10-21 00:00:00
abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12115503
更新日期：2014-11-19 00:00:00
abstract：:Collagen is widely used in the pharmaceutical, tissue engineering, nutraceutical, and cosmetic industries. In this study, acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were extracted from the skin of red stingray, and its physicochemical and functional properties were investigated. The yields of ASC an...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100558
更新日期：2019-09-28 00:00:00
abstract：:Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030186
更新日期：2019-03-21 00:00:00
abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100349
更新日期：2018-09-24 00:00:00
abstract：:Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9122553
更新日期：2011-12-01 00:00:00
