Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator.


:Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for complement-targeted therapeutics development. Arenicins from the sea polychaete Arenicola marina, the classical example of peptides with a β-hairpin structure stabilized by a disulfide bond, were shown earlier to be among the most prospective regulators. Here, we investigate the link between arenicins' structure and their antimicrobial, hemolytic and complement-modulating activities using the derivative Ar-1-(C/A) without a disulfide bond. Despite the absence of this bond, the peptide retains all important functional activities and also appears less hemolytic in comparison with the natural forms. These findings could help to investigate new complement drugs for regulation using arenicin derivatives.


Mar Drugs


Marine drugs


Krenev IA,Umnyakova ES,Eliseev IE,Dubrovskii YA,Gorbunov NP,Pozolotin VA,Komlev AS,Panteleev PV,Balandin SV,Ovchinnikova TV,Shamova OV,Berlov MN




Has Abstract


2020-12-10 00:00:00










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    journal_title:Marine drugs

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    authors: Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

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    journal_title:Marine drugs

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    authors: Ding H,Ruan Z,Kou P,Dong X,Bai J,Xiao Q

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    journal_title:Marine drugs

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    authors: Chaves-Peña P,de la Coba F,Figueroa FL,Korbee N

    更新日期:2019-12-28 00:00:00

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    authors: Ding L,Ren L,Li S,Song J,Han Z,He S,Xu S

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    authors: Barra M,Llanos-Rivera A,Cruzat F,Pino-Maureira N,González-Saldía RR

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ragini K,Piggott AM,Karuso P

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  • Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products.

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    journal_title:Marine drugs

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    authors: Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

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  • Evaluation of Rapid, Early Warning Approaches to Track Shellfish Toxins Associated with Dinophysis and Alexandrium Blooms.

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Cornara L,Pastorino G,Borghesi B,Salis A,Clericuzio M,Marchetti C,Damonte G,Burlando B

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    journal_title:Marine drugs

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xi Z,Bie W,Chen W,Liu D,van Ofwegen L,Proksch P,Lin W

    更新日期:2013-08-26 00:00:00

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang CY,Tseng WR,Ahmed AF,Chiang PL,Tai CJ,Hwang TL,Dai CF,Sheu JH

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Vallet M,Meziane T,Thiney N,Prado S,Hubas C

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: García-Altares M,Casanova A,Bane V,Diogène J,Furey A,de la Iglesia P

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rodríguez-Luna A,Ávila-Román J,González-Rodríguez ML,Cózar MJ,Rabasco AM,Motilva V,Talero E

    更新日期:2018-10-10 00:00:00

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Qi H,Sheng J

    更新日期:2015-05-29 00:00:00

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kasper B,Reichardt P,Pink D,Sommer M,Mathew M,Rauch G,Hohenberger P

    更新日期:2015-01-13 00:00:00

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    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Musumeci MA,Lozada M,Rial DV,Mac Cormack WP,Jansson JK,Sjöling S,Carroll J,Dionisi HM

    更新日期:2017-04-09 00:00:00