Abstract：
:There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper, the synthesis of pelorol has been completed, and the synthesis of some intermediates has been optimized and scaled up. Five pelorol analogs have also been prepared. Preliminary biological activity testing demonstrated that compounds 5 and 6 might be potential lead compounds for cancer therapy.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Luo Y,Chen H,Weng J,Lu Gdoi
10.3390/md14060118subject
Has Abstractpub_date
2016-06-21 00:00:00issue
6issn
1660-3397pii
md14060118journal_volume
14pub_type
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