Antiviral lead compounds from marine sponges.


:Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hoped to be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed.


Mar Drugs


Marine drugs


Sagar S,Kaur M,Minneman KP




Has Abstract


2010-10-11 00:00:00










  • Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

    abstract::Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: García-Vilas JA,Martínez-Poveda B,Quesada AR,Medina MÁ

    更新日期:2015-12-22 00:00:00

  • 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

    abstract::Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

    更新日期:2017-08-19 00:00:00

  • Ω3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats.

    abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Herrera EA,Farías JG,González-Candia A,Short SE,Carrasco-Pozo C,Castillo RL

    更新日期:2015-02-04 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期:2017-02-28 00:00:00

  • Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

    abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Boucle S,Melin C,Clastre M,Guillard J

    更新日期:2015-01-19 00:00:00

  • New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism.

    abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

    更新日期:2018-11-16 00:00:00

  • 5-Episinuleptolide Decreases the Expression of the Extracellular Matrix in Early Biofilm Formation of Multi-Drug Resistant Acinetobacter baumannii.

    abstract::Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tseng SP,Hung WC,Huang CY,Lin YS,Chan MY,Lu PL,Lin L,Sheu JH

    更新日期:2016-07-29 00:00:00

  • Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea).

    abstract::A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to dis...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee CH,Kao CY,Kao SY,Chang CH,Su JH,Hwang TL,Kuo YH,Wen ZH,Sung PJ

    更新日期:2012-02-01 00:00:00

  • Preparation of chitosan nanocomposites with a macroporous structure by unidirectional freezing and subsequent freeze-drying.

    abstract::Chitosan is the N-deacetylated derivative of chitin, a naturally abundant mucopolysaccharide that consists of 2-acetamido-2-deoxy-β-d-glucose through a β (1→4) linkage and is found in nature as the supporting material of crustaceans, insects, etc. Chitosan has been strongly recommended as a suitable functional materia...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Aranaz I,Gutiérrez MC,Ferrer ML,del Monte F

    更新日期:2014-11-24 00:00:00

  • Cephalopods as vectors of harmful algal bloom toxins in marine food webs.

    abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Lopes VM,Lopes AR,Costa P,Rosa R

    更新日期:2013-09-06 00:00:00

  • Terpenoids from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3 and Their Bioactivities.

    abstract::A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng Z,Liu W,Fan R,Han S,Li Y,Cui X,Zhang J,Wu Y,Lv X,Zhang Y,Luo Z,Alias SA,Xu W,Li Q

    更新日期:2020-03-16 00:00:00

  • Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.

    abstract::Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kumar SR,Hosokawa M,Miyashita K

    更新日期:2013-12-16 00:00:00

  • Production of New Antibacterial 4-Hydroxy-α-Pyrones by a Marine Fungus Aspergillus niger Cultivated in Solid Medium.

    abstract::Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ding L,Ren L,Li S,Song J,Han Z,He S,Xu S

    更新日期:2019-06-10 00:00:00

  • Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems.

    abstract::Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Hamman JH

    更新日期:2010-04-19 00:00:00

  • A Place to Call Home: An Analysis of the Bacterial Communities in Two Tethya rubra Samaai and Gibbons 2005 Populations in Algoa Bay, South Africa.

    abstract::Sponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the spon...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Waterworth SC,Jiwaji M,Kalinski JJ,Parker-Nance S,Dorrington RA

    更新日期:2017-03-25 00:00:00

  • Fucoidan from Marine Brown Algae Inhibits Lipid Accumulation.

    abstract::In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park MK,Jung U,Roh C

    更新日期:2011-01-01 00:00:00

  • Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity.

    abstract::This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Alhakamy NA,Fahmy UA,Ahmed OAA,Caruso G,Caraci F,Asfour HZ,Bakhrebah MA,N Alomary M,Abdulaal WH,Okbazghi SZ,Abdel-Naim AB,Eid BG,Aldawsari HM,Kurakula M,Mohamed AI

    更新日期:2020-04-24 00:00:00

  • Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells.

    abstract::Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ham J,Lim W,Kim K,Heo YM,Ryu SM,Lee D,Kim JJ,Song G

    更新日期:2019-06-03 00:00:00

  • Effects of long chain fatty acid synthesis and associated gene expression in microalga Tetraselmis sp.

    abstract::With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Adarme-Vega TC,Thomas-Hall SR,Lim DK,Schenk PM

    更新日期:2014-06-04 00:00:00

  • Clinical trial: marine lipid suppositories as laxatives.

    abstract:UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...

    journal_title:Marine drugs

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ormarsson OT,Geirsson T,Bjornsson ES,Jonsson T,Moller P,Loftsson T,Stefansson E

    更新日期:2012-09-01 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Pectenotoxin-2 from marine sponges: a potential anti-cancer agent-a review.

    abstract::Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kim GY,Kim WJ,Choi YH

    更新日期:2011-01-01 00:00:00

  • New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

    abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

    更新日期:2014-12-29 00:00:00

  • Molecular and Morphological Toxicity of Diatom-Derived Hydroxyacid Mixtures to Sea Urchin Paracentrotus lividus Embryos.

    abstract::Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Albarano L,Ruocco N,Ianora A,Libralato G,Manfra L,Costantini M

    更新日期:2019-03-01 00:00:00

  • Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1.

    abstract::Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang W,Liao Y,Zhang B,Gao M,Ke W,Li F,Shao Z

    更新日期:2019-01-10 00:00:00

  • Lipidomic Approaches towards Deciphering Glycolipids from Microalgae as a Reservoir of Bioactive Lipids.

    abstract::In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

    更新日期:2016-05-19 00:00:00

  • Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis.

    abstract::Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Shubina LK,Makarieva TN,Denisenko VA,Popov RS,Dyshlovoy SA,Grebnev BB,Dmitrenok PS,von Amsberg G,Stonik VA

    更新日期:2020-08-30 00:00:00

  • Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice.

    abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Han EJ,Kim HS,Sanjeewa KKA,Jung K,Jee Y,Jeon YJ,Fernando IPS,Ahn G

    更新日期:2020-11-26 00:00:00

  • Aplisulfamines, new sulfoxide-containing metabolites from an aplidium tunicate: absolute stereochemistry at chiral sulfur and carbon atoms assigned through an original combination of spectroscopic and computational methods.

    abstract::Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone R

    更新日期:2012-01-01 00:00:00

  • New 9α-Hydroxy-5α,6α-epoxyhydroxysterols from the Vietnamese Marine Sponge Ircinia echinata.

    abstract::Chemical investigation of the methanol extract of the Vietnamese marine sponge Ircinia echinata led to the isolation of six new 9α-hydroxy-5α,6α-epoxysterols: 5α,6α-epoxycholesta-7,22(E)-dien-3β,9α-diol (1), 5α,6α-epoxycholesta-7,24(28)-dien-3β,9α-diol (2), (24R)-5α,6α-epoxy-24-ethyl-cholesta-7-en-3β,9α-diol (3), 5α,6...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Trinh TTV,Truong BN,Longeon A,Doan TMH,Deville A,Chau VM,Pham VC,Bourguet-Kondracki ML

    更新日期:2018-11-01 00:00:00